CCT2 Promotes Immune Escape in Colorectal Cancer by Regulating the JAK1‐STAT3‐PD‐L1 Axis

TREM1 Blockade Reprograms Tumor‐Associated Macrophages and Improves Anti‐PD‐1 Efficacy in Gastric Cancer

The objective response rate of immune checkpoint inhibitors in patients with gastric cancer is limited. Targeting specific subtypes of macrophages holds promise for expanding the potential population sensitive to immune checkpoint inhibitors. This study aims to evaluate the key role of TREM1+tumor‐associated macrophage...

PCK1 promotes gastric cancer progression by activating the SRC1-JAK1-STAT3 signaling axis

Highlights • PCK1 is overexpressed in gastric cancer and promotes tumor growth and metastasis.• PCK1 activates the SRC1-JAK1-STAT3 cascade in gastric cancer cells.• The PCK1-SRC1-STAT3 pathway is a potential therapeutic target for gastric cancer.

RETRACTED ARTICLE: IRF1 inhibits the proliferation and metastasis of colorectal cancer by suppressing the RAS-RAC1 pathway

FJX1 drives FOLFOX resistance via PPARγ-mediated EMT and serves as a prognostic biomarker in colorectal cancer

Highlights • FJX1 is overexpressed in CRC and predicts poor patient survival.• FJX1 drives FOLFOX resistance by directly binding and activating PPARγ.• FJX1-PPARγ interaction promotes EMT, proliferation, and tumor migration.• Disrupting the FJX1-PPARγ axis with FX909 restores chemosensitivity.

CARM1: an epigenetic brake on cDC1-mediated antitumor immunity.

The underlying mechanism of tumor microenvironment-induced dysfunction of conventional type 1 dendritic cells (cDC1) remains unclear. Zhang et al. identify transforming growth factor β-driven coactivator-associated arginine methyltransferase 1 (CARM1) as an epigenetic inhibitor of cDC1 cross-presentation. CARM1 is a ce...

Integrated Transcriptomic Analysis and Machine Learning Identify THY1 as a Key Regulator of Cancer‐Associated Fibroblast Infiltration, Promoting Malignant Progression and Immune Escape in Gastric Cancer

Heterogeneity in cancer‐associated fibroblast (CAF) infiltration within the tumor microenvironment is closely associated with gastric cancer progression and immune evasion; however, precise CAF‐related diagnostic markers and actionable therapeutic targets remain scarce.