CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment

This study provides evidence for a key role of TNFR1, as expressed by malignant cells, in orchestrating a pro-tumor immunosuppressive environment through secondary inflammatory mediators. Results highlight the relevance of interfering TNFα/TNFR1 in cancer immunotherapy.

Cuproptosis enters the cancer-immunity circuit.

In this issue of Cell, Lei et al. reveal a reciprocal circuit in which cuproptotic tumor cells promote dendritic cell activation and CD8+ T cell priming, whereas T cell-derived IFN-γ sensitizes tumor cells to FDX1-dependent cuproptosis. This self-reinforcing interaction provides a mechanistic rationale for combining cu...

Tumor cells recruit macrophage bodyguards to outlast chemotherapy.

In Cell Press Blue, Carvalho et al. identify spatially organized tumor-macrophage niches, EMT-like CD44high cancer cells paired with SPP1/PARP14high macrophages, that drive chemoresistance in bladder cancer. PARP14 inhibition can flip this protective niche into an inflammatory, cisplatin-sensitizing state.

CD8+ T cells kill tumors by proxy

CARM1: an epigenetic brake on cDC1-mediated antitumor immunity.

The underlying mechanism of tumor microenvironment-induced dysfunction of conventional type 1 dendritic cells (cDC1) remains unclear. Zhang et al. identify transforming growth factor β-driven coactivator-associated arginine methyltransferase 1 (CARM1) as an epigenetic inhibitor of cDC1 cross-presentation. CARM1 is a ce...

TREM1 Blockade Reprograms Tumor‐Associated Macrophages and Improves Anti‐PD‐1 Efficacy in Gastric Cancer

The objective response rate of immune checkpoint inhibitors in patients with gastric cancer is limited. Targeting specific subtypes of macrophages holds promise for expanding the potential population sensitive to immune checkpoint inhibitors. This study aims to evaluate the key role of TREM1+tumor‐associated macrophage...