Author

A. Grigoriadis

3 papers indexed here

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Open access Sep 2026

PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer

Most Triple Negative Breast Cancers (TNBCs) are p53 mutant high-grade invasive ductal carcinomas with a basal-like transcriptional programme. A large proportion of TNBCs also have mutation signatures indicating defective homologous recombination (HR) DNA repair. While HR deficiency is mutagenic and oncogenic, it can al...

V. Amodeo, D. Weekes, Nicolae Balan et al. · Nature Communications · 0 citations

Open access Aug 2026

Genome-wide DNA methylation profiling of triple-negative breast cancer uncovers epigenetic biomarkers of tumor identity and the immune microenvironment

DNA methylation deregulation is an essential feature of tumor biology, influencing cancer formation and pathogenesis. Analyses of DNA methylation in bulk cancer specimens are challenging due to the high data dimensionality, noise, and mixture of different cell types. Here, we characterized methylation dynamics in cance...

Iñaki Sasiain, D. F. Nacer, M. Jönsson et al. · npj Breast Cancer · 1 citation

Open access Aug 2026

CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity

CD1d targeting reshapes tumor immune infiltrates, suppresses tumor growth, and enhances immunotherapy efficacy, suggesting an actionable pathway for therapeutic intervention.

Lauren Evans, Maria Conde Poole, Cenk Celik et al. · Journal of Experimental Medi... · 0 citations