Design, synthesis and multitarget evaluation of cyclopropyl-appended thiohydantoin derivatives as dual cholinesterase and COX inhibitors with antioxidant activity: a combined experimental and computational study

Amina Hussain Rafaqat Hussain Hina Sarfraz Uzma Azam Muhammad Hasnat Shoaib Khan Sibghat Mansoor Rana Y. Asiri Zainab

Sep 2026 · Journal of Computer-Aided Molecular Design · Vol 40 · 0 citations · 61 references

Medicine

TL;DR

Together with their dual cholinesterase inhibitory activities, compounds 6a and 6c represent promising multifunctional in vitro lead candidates for further development against neurodegenerative disorders associated with neurodegenerative disorders associated with neuroinflammation and oxidative stress.

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