Design, synthesis, biological activity and computational simulation evaluation of pyrimidine-2-aminoacetamide derivatives as cholinesterase inhibitors

Yi-Xuan Wang Shi-Hao Qin Qiang Liu Xue-Wei Zhou Chao-Yue Zhang Zhengyue Ma

Aug 2026 · Medicinal Chemistry Research · Vol 35, pp. 1801 - 1818 · 0 citations · 43 references

Medicine

TL;DR

Compound 17v represents a promising lead compound for anti-Alzheimer's therapy and may possess multi-target neuroprotective potential and a favorable preliminary safety profile, supporting its further investigation as a potential therapeutic candidate for Alzheimer’s disease.

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