It is proposed that macrophages represent a critical mechanistic link between hAMSC-sEV therapy and coordinated tissue repair and may suppress chronic inflammation while simultaneously supporting osteogenesis and neovascularization.
Osteonecrosis of the femoral head (ONFH) is a progressive ischemic bone disorder that may lead to subchondral fracture, femoral-head collapse, and total hip arthroplasty. Impaired regeneration reflects persistent ischemia, endothelial dysfunction, defective angiogenesis and bone remodeling, inflammation, oxidative stre...
S. Mukhlis, M. Imanbekova, D. Saginova et al.· Cells· 0 citations
This review synthesizes current evidence on endothelial EV cargo and discusses how aging remodels vesicle composition and function to drive vascular–bone uncoupling, and compares bioengineering strategies aimed at correcting senescence-associated cargo liabilities and improving translational readiness.
Jin-Xin Zhang, Xing-Chen Wei, Na Han· International Journal of Mol...· 0 citations
Aging disrupts skeletal homeostasis, resulting in impaired fracture healing, increased risk of nonunion, and reduced regenerative capacity. These deficits are associated with dysregulated inflammation, impaired angiogenesis, and reduced osteogenesis, while current treatments remain limited in aged populations. This rev...
Mariana Moraes de Lima Perini, Ji-Liang Li· Current Osteoporosis Reports· 0 citations
Extracellular vesicles (EVs) have emerged as promising cell-free therapeutic agents for bone regeneration due to their ability to modulate osteogenesis, angiogenesis, and immune responses. This review summarizes the current knowledge on EV biology, including their classification, biogenesis, and molecular cargo, with a...
M. Jäger, A. Sowislok· Bioengineering· 0 citations
BACKGROUND
Osteoradionecrosis of the jaw (ORNJ) is a severe radiotherapy complication with unclear molecular drivers. CDKN1A/p21 is upregulated by radiation-induced DNA damage, but its role in ORNJ remains unknown.
METHODS
An ORNJ mouse model was established. Single-cell RNA-sequencing of irradiated mandibles was ana...
Jia-Ying Shi, Shu-Xian Lin, Jia-Yu Yan et al.· Oral Diseases· 0 citations
