MCAT-mediated mitochondrial fatty acid metabolism regulates Lauren subtype divergence and suppresses gastric cancer progression through ROS/P53-dependent mitophagy and ferroptosis.

Yu-Fei Wang Meng Zhu Xin Yin Tian-Yi Fang Lei Zhang Yu-Juan Jiao Hong-Xin Wang Zi-Pu Dong Teng-Teng Liu Ying-Wei Xue

Sep 2026 · Cell Death and Differentiation · 0 citations · 38 references

Medicine

TL;DR

Findings establish Malonyl-CoA:ACP transacylase (MCAT), a Lauren subtype-associated gene encoding a key mitochondrial fatty acid synthesis (mtFAS) enzyme, as a metabolic switch that links ROS/P53-dependent cell death and therapeutic target for GC.

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