Jul 2026· International Journal of Biological Macromolecules· Vol 378, pp.
153779
· 0 citations· 43 references
Medicine
TL;DR
In vitro results indicate that the CSDX3 hydrogel exhibits excellent antibacterial, reactive oxygen species (ROS) scavenging, and angiogenic properties, and this multifunctional injectable hydrogel offers an effective treatment option for diabetic wounds.
Abstract
Bacterial infection and oxidative stress are critical factors affecting diabetic wound healing. Regulating the wound microenvironment by suppressing bacterial infection, oxidative stress, while promoting angiogenesis presents a major challenge in diabetic wound healing. Through Schiff base crosslinking between dihydrocaffeic acid-modified chitosan (HCA) and oxidized dextran (ODX), a three-dimensional network structure of injectable hydrogel (CSDX3) was constructed, enabling controlled sustained release of loaded copper ions. In vitro results indicate that the CSDX3 hydrogel exhibits excellent antibacterial, reactive oxygen species (ROS) scavenging, and angiogenic properties. The hydrogel CSDX3 accelerates the healing of diabetic wounds in vivo by reducing inflammation, stimulating angiogenesis, and enhancing collagen fiber deposition. Therefore, this multifunctional injectable hydrogel offers an effective treatment option for diabetic wounds.
Diabetic wounds are prone to bacterial infection and difficult to heal due to chronic inflammation and hyperglycemic microenvironment. Here we developed a novel bioactive hydrogel with multifunctional tunable properties, including biocompatibility, pH-response, anti-inflammatory activity, and the ability to promote dia...
Zi-Rui Fan, Shi-Xin Wang, Si-Tong Bian et al.· International Journal of Bio...· 0 citations
A composite hydrogel incorporating organic-inorganic peptide-zinc nanoflowers incorporating organic-inorganic peptide-zinc nanoflowers for sustained local delivery regulated the diabetic wound microenvironment through antibacterial, antioxidant, anti-inflammatory, and pro-angiogenic activities, thereby promoting tissue...
Xin Dan, Han Chen, Song-Jie Li et al.· Regenerative Biomaterials· 0 citations
Chronic diabetic wounds remain a major clinical challenge due to persistent inflammation, excessive reactive oxygen species (ROS), and impaired angiogenesis. However, many wound dressings do not coordinate therapeutic delivery with the changing oxidative and angiogenic requirements of diabetic wound healing. Herein, we...
Hua-Jian Zhu, Fang-Min Jiao, Peng Wang et al.· International Journal of Bio...· 0 citations
We describe adhesive and self-healing hydrogels of chitosan functionalized with catechol groups (Chit-Cat) and crosslinked with β-glycerophosphate for the treatment of chronic diabetic wounds. Catechol functionalization enhanced the antibacterial activity of the hydrogels, eliminating both Gram-negative and Gram-positi...
Cátia Correia, Rita O. Sousa, Nor Amirrah Ibrahim et al.· International Journal of Bio...· 0 citations
The hyperglycemic microenvironment and persistent bacterial infections of diabetic patients significantly inhibit the wound healing process. Meanwhile, the developed adhesive hydrogel for wound healing still faces challenge of secondary damage during dressing change. Herein, a diabetic wound microenvironment self-adapt...
Xi-Ying Chen, Yu-Sha Zeng, Chen-Yue Tao et al.· International Journal of Bio...· 0 citations
This multifunctional hydrogel provides a promising strategy for diabetic wound management by integrating antibacterial potential and tissue regeneration by integrating antibacterial potential and tissue regeneration.
