Aug 2026· Biomaterials Science· 0 citations· 35 references
Medicine
TL;DR
This multifunctional hydrogel provides a promising strategy for diabetic wound management by integrating antibacterial potential and tissue regeneration by integrating antibacterial potential and tissue regeneration.
Abstract
Chronic diabetic wounds remain a major clinical challenge owing to persistent bacterial infection, prolonged inflammation, excessive exudation, and impaired tissue regeneration. Herein, an injectable thermosensitive hydrogel was developed by integrating N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride with aldehyde-functionalized Pluronic F127 for epidermal growth factor (EGF) delivery and diabetic wound repair. The hydrogel forms a dual-crosslinked network through temperature-induced micellization and dynamic Schiff base bonding, exhibiting rapid gelation under physiological conditions, shear-thinning behavior, and self-healing properties. In vitro, the hydrogel provides a sustained release profile of EGF exhibiting effective antibacterial activity against Gram-positive S. aureus. In vivo studies in streptozotocin-induced diabetic rats demonstrate significantly accelerated wound healing, achieving 83% wound closure within 14 days compared to 45% in the control group, along with enhanced tissue regeneration characteristics, including improved collagen deposition. This multifunctional hydrogel provides a promising strategy for diabetic wound management by integrating antibacterial potential and tissue regeneration.
An integrated approach combining network pharmacology, molecular docking, molecular dynamics simulations, and experimental validation revealed that the therapeutic efficacy of sustained local α-MG delivery involves the modulation of the PPAR-γ pathway.
Yuan Ma, Xu Liu, Zhewen Deng et al.· International Journal of Bio...· 0 citations
Findings suggest that the synthesized hydrogel (BSG‐CHI) provides a favorable microenvironment for tissue regeneration and wound management applications.
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In vitro and in vivo results demonstrate that the injectable dual-dynamic covalent hydrogel promotes macrophage polarization toward the anti-inflammatory M2 phenotype, alleviates inflammatory responses, enhances angiogenesis, and accelerates skin regeneration.
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Stable hydrogel formation with favorable porous architecture, swelling behavior, thermal stability, and homogeneous distribution of nanovesicles was well established and exhibited excellent biocompatibility, hemocompatibility, and enhanced cell-material interactions.
Rizos Evangelos Bikiaris, Ioanna Koumentakou, A. Niti et al.· ACS Applied Bio Materials· 0 citations
A multifunctional hydrogel dressing was constructed from carboxymethyl chitosan and oxidized dextran as the dynamic network, incorporating CeO2 nanozymes for early anti-inflammatory and antioxidant effects and PLGA microspheres loaded with astragaloside IV for sustained pro-regeneration.
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Abstract Infected wounds represent a significant clinical burden owing to persistent infection, excessive inflammation, and impaired tissue regeneration. To overcome these limitations, we developed a sprayable N-succinyl chitosan/Pluronic F127 (NSC/PF127) hydrogel incorporating MoO₂ nanoparticles, ciprofloxacin, and fibroblast growth factor-2 (FGF-2). At body temperature, the hydrogel rapidly transitions from a solution to a gel and responds to both pH changes and near-infrared (NIR) irradiation. MoO₂ exhibits NIR-mediated photothermal activity, while CIP and FGF-2 are released in a sustained and pH-dependent manner, thereby maintaining antibacterial efficacy and growth factor bioactivity. In vitro studies demonstrated excellent cytocompatibility and significantly enhanced fibroblast and keratinocyte migration. The combined photothermal effect and antibiotic therapy effectively suppressed bacterial growth and disrupted established biofilms. In a rat model of Staphylococcus aureus-infected full-thickness wounds, the hydrogel composite significantly accelerated healing, reduced inflammation, promoted collagen deposition and angiogenesis, and enhanced tissue regeneration. Biochemical and gene expression analyses further indicated reduced oxidative stress and improved tissue regeneration. This multifunctional, sprayable hydrogel combines targeted antibacterial action with sustained pro-regenerative signaling, offering a promising strategy for further preclinical investigations of infected wound management.
Zhi-Rui Li, Ming-Xing Lei, Chen Chen et al.· Drug Delivery· 0 citations
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