Targeting GLS and LPIN2 in renal fibroblasts: potential therapeutic targets for kidney stone disease identified by integrated multi-omics analysis

Integrated Transcriptomic and Machine Learning Analyses Identify KCNN3 and TLR10 as Candidate Cell-Type-Associated Molecules in Idiopathic Membranous Nephropathy

Purpose Idiopathic membranous nephropathy (IMN) is a common immune-mediated glomerular disease, but the key molecules driving its progression remain unclear. This study integrated bulk RNA sequencing (RNA-seq), machine learning, and single-cell RNA sequencing (scRNA-seq) to screen and preliminarily validate key molecul...

Moesin emerges as a potential exploratory biomarker associated with renal fibrosis in diabetic kidney disease

The combined bioinformatic and experimental data suggest that MSN may serve as an exploratory biomarker for pathological assessment of DKD.

Single-cell transcriptomics and multi-omics integration identify necroptosis-driven core targets and tubular-immune crosstalk in chronic kidney disease.

BACKGROUND Current pharmacotherapies for chronic kidney disease (CKD) are limited by adverse effects and a "one-target-one-drug" paradigm. Necroptosis is a key driver of renal deterioration, yet its regulatory network remains poorly defined. Modified Da-Huang-Fu-Zi Decoction (DHFZ) has shown clinical efficacy, although...

Identification of key molecules and pathways in CaOx crystal-induced renal injury based on metabolomics and proteomics.

Baicalein attenuates extracellular matrix remodeling via FN1 in diabetic kidney disease: a multi-omics, machine-learning and mesangial-cell rescue study

Methods Three transcriptomic cohorts, GSE30528, GSE96804, and GSE104948, comprising 62 DKD and 59 control samples, were integrated for differential expression and weighted gene co-expression network analyses. Candidate genes were prioritized using disease databases, protein–protein interaction analysis, 113 machine-lea...

Multi-omics integration reveals the CTSK-cholesterol metabolic axis and the cholesterol-RORA/LDLR paracrine axis in SPP1+ macrophages as mediators of 6PPD-quinone-induced idiopathic pulmonary fibrosis.

OBJECTIVE This study aimed to screen and identify potential biomarkers linking 6PPD-quinone (6PPD-Q) exposure to idiopathic pulmonary fibrosis (IPF), generating a mechanistic hypothesis for future experimental investigation and therapeutic development. METHODS 6PPD-Q-related genes and IPF-associated genes were obtain...