Aug 2026
Targeting GLS and LPIN2 in renal fibroblasts: potential therapeutic targets for kidney stone disease identified by integrated multi-omics analysis
This study identified GLS and LPIN2 as key genes promoting fibroblast activation, calcium deposition and osteogenic differentiation in KS, constructed a risk prediction model, and identified digoxin as a potential therapeutic agent, providing new strategies for the precise diagnosis and treatment of KS.
Yao-Feng Wang, Yan-Chao Gong, Yuan-Kai Li et al.
· Urolithiasis · 1 citation