USP8 stabilizes GPR37 via deubiquitination to regulate colorectal cancer progression through the NRF2/SLC7A11/GPX4 pathway

GPR39 Suppresses Ferroptosis via the Nrf2/SLC7A11 Axis and Reduces the Sensitivity of Colorectal Cancer to Anti‐PD‐1 Immunotherapy

In vivo, GPR39 knockdown significantly potentiated the antitumor activity of PD‐1 blockade, as evidenced by suppressed tumor progression accompanied by enhanced infiltration of CD8+ T cells, whereas ferroptosis inhibition abrogated these effects.

USP7/SETDB1 promotes non-small cell lung cancer progression by regulating ferroptosis via NRF2/SLC7A11/GPX4 axis.

Non-small cell lung cancer (NSCLC) is a malignant tumor with high morbidity and mortality. Given the reported associations of both SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) with various cancers and ubiquitin-specific protease 7 (USP7) with NSCLC progression, this study aims to elucidate the role...

USP2-Mediated Deubiquitination of β-catenin Drives Colorectal Adenocarcinoma Progression and Immune Evasion.

METTL1/USP48 Axis Stabilizes LCN2 Expression to Promote the Malignant Phenotypes of Cutaneous Squamous Cell Carcinoma.

Clinically, these findings identify the METTL1/USP48/LCN2 pathway as a potential therapeutic target for cSCC and elucidated a novel oncogenic axis in cSCC, wherein METTL1 stabilized USP48 mRNA through m7G methylation modification, and USP48 in turn deubiquitinated and stabilized LCN2 protein.

Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO-1/GPX4 Regulatory Axis.

Multi-dimensional experiments reveal BA may regulate ferroptosis via the potential STAT3/HO-1/GPX4 signaling axis and is a promising therapeutic alternative to conventional chemotherapy, which is limited by severe systemic toxicity.

UBE2S Promotes KIRC Progression by Regulating CDC20 Expression and Suppressing FDX1-Mediated Cuproptosis, While Promoting M2 Macrophage Polarization.

This study aims to investigate the biological function, molecular mechanisms, and impact on the tumor microenvironment of the ubiquitin-conjugating enzyme E2S (UBE2S) in the progression of kidney renal clear cell carcinoma (KIRC). Based on the TCGA and GEPIA databases, the relationship between UBE2S expression and pati...