Sep 2026· Applied Biochemistry and Biotechnology· 0 citations· 27 references
Medicine
TL;DR
Clinically, these findings identify the METTL1/USP48/LCN2 pathway as a potential therapeutic target for cSCC and elucidated a novel oncogenic axis in cSCC, wherein METTL1 stabilized USP48 mRNA through m7G methylation modification, and USP48 in turn deubiquitinated and stabilized LCN2 protein.
The results suggest that the pro-tumorigenic effects of XPR1 in thyroid carcinoma cells, manifested by increased cell growth, motility, invasiveness, and reduced susceptibility to apoptosis, may be partly associated with NF-κB signaling.
J. You, Tong-Xin Zou, Bo-Xiu Wang et al.· Discover medicine· 0 citations
HIST1H4L was significantly upregulated in SCLC tumors versus normal tissues and enriched in DNA transcription-related pathways and correlated with poor patient survival; critically, high HIST1H4L expression correlated with poor patient survival.
Shi-Cheng Feng, Min Feng, Zhi-Qiang Lu et al.· Frontiers in Oncology· 0 citations
Head and neck squamous cell carcinoma (
HNSCC
) is a prevalent malignancy with poor clinical prognosis. While acyl-CoA thioesterases (
ACOTs
) are recognized as key regulators of lipid metabolism, their contributions to HNSCC pathogenesis are not well understood. ACOT7 is of particular interest as it cataly...
Zhen-Ning Jin, Jia-Yi Peng, Diana Messadi et al.· Cancer & Metabolism· 0 citations
This study aims to investigate the biological function, molecular mechanisms, and impact on the tumor microenvironment of the ubiquitin-conjugating enzyme E2S (UBE2S) in the progression of kidney renal clear cell carcinoma (KIRC). Based on the TCGA and GEPIA databases, the relationship between UBE2S expression and pati...
Silencing of TMEM33 markedly suppresses CRC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) both in vitro and in vivo, and significantly reduces subcutaneous tumor growth and pulmonary metastatic burden.
Rui Li, Li Zhao, Nan-Nan Chai et al.· Human Cell· 0 citations
