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Open access Aug 2026

Dopamine serves as an independent gain regulator to shape striatal control of movement

Findings support that DA does not simply encode spontaneous movement, but acts as a pathway-specific gain controller that dynamically tunes the transformation of glutamatergic input into SPN output to bias locomotor-state transitions in vivo.

Jingheng Zhou, Riley M. Harper, Amy B. Papaneri et al. · 0 citations
Sep 2026

Dissociable cortical-hippocampal dopamine dynamics support memory-guided behavior.

Flexible behavior depends on neural mechanisms that integrate memory with ongoing motivational demands. Studies have revealed dopamine (DA) to have an essential role in mediating memory, behavioral flexibility, and decision-making, yet the dopaminergic contributions within prefrontal-hippocampal circuits remain poorly...

Albit Caban-Murillo, Michelle Surets, Celine Chien et al. · 0 citations
Open access Oct 2026

Dopamine release-associated striatal blood oxygenation and whole-brain dynamics during associative learning

Dopaminergic signaling in the nucleus accumbens (NAc) is central to reward-based learning, but its relationship to brain-wide hemodynamics remains unclear. Using concurrent fMRI and dopamine photometry in awake, behaving mice, we reveal that associative learning induces a gradual temporal shift in NAc blood oxygenation...

Amir Lawen, Isabella K. Succi, Daniela Lichtman et al. · 0 citations
Open access Sep 2026

558. Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behavior

Abstract Background Behavioral flexibility—the ability to update actions when contingencies change—is essential for survival and depends heavily on basal ganglia circuitry. Although the basal ganglia integrate contextual, reward, and motor-planning signals to enable adaptive control, most mechanistic work on behavioral...

S. Kang, M.-A. Yang, J. Lee et al. · 0 citations
#reinforcement learning Open access Sep 2026

Cholinergic-dependent dopamine signals in mouse dorsomedial striatum are regulated by frontal but not sensory cortices

Everyday decisions depend on associations between sensory stimuli, actions, and outcomes. The striatum supports these sensorimotor associations through dopamine-dependent plasticity. Recent work has characterized a local striatal microcircuit in which cholinergic interneurons (CINs) modulate dopamine release via activa...

Hannah C. Goldbach, Rachele Rimondini, Evan S. Swanson et al. · 0 citations

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