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Review

Generation of eight-cell embryo-like cells from human pluripotent stem cells.

Md. Abdul Mazid Yun-Pan Li Min-Die Zhao Li-Xin Fu Hao Liu Yu Jiang Wen-Qi Jia Jun-Jian Lai Jin-Xiu Li Hai-Wei Li Babangida Jabir Saeed Amash Manzoor Zhi-Wei Luo Yiwei Lai Liang Wu Yi Zou Chaiyaboot Ariyachet C. Ward Chuan Liu Longqi Liu Miguel A. Esteban Wen-Juan Li
Sep 2026 · Nature Protocols · 0 citations · 60 references
Medicine

TL;DR

The approach provides a valuable model for studying human early embryogenesis, particularly the molecular events surrounding ZGA, and is expected that an individual with ~1 year of experience working with human PSC culture would be able to carry out this protocol.

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