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RISING STAR ABSTRACTS Beyond Ensemble Measurements: Resolving Antigen Binding and Conformational Heterogeneity in Multispecific Antibodies

Fanny C. Liu Thais Pedrete Andrew H. Beaven Harsha P Gunawardena C. Bleiholder J. Shuster Lin Wu J. Mill Dominique A. Baldwin Michaela M. Morhaus Judith A. Simcox A. E. Ibarra Kendra G. Selby P. Corsetti Tina C. Dang Wenxin Wu Ling-Jun Li Claire E. Boos M. Scalf James E. Bruce M. Shortreed Rachel M. Miller Nicholas E Bollis N. Sherer Lloyd M. Smith M. L. Robinson Wenyu Liu Giorgia Benegiamo Miller T. Williams G. Smith Samuel Klein Johan Auwerx Joshua J. Coon N. Vu H. Trần Marilyn Frézier Hsin-Ju Chan Isabella R. Clemmer Wangqin Ge Holden T. Rogers Zhan Gao Matthew S. Fischer Ying Ge Andrew J. Perciaccante Yanlong Zhu A. Barnwal David Inman Man Wang Song Jin S. Ponik
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TL;DR

These findings reveal that the RSV F antigen recognizes both the wild-type and AAS-mutated bispecific antibodies in a conformation-dependent manner, with binding preferentially observed for larger conformations.

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