Enhancing phytosterol tolerance and Repeated-Batch androstenedione production in Mycolicibacterium by modulating global acylation levels.

Yu-Ying Liu Yang Huang Chen-Ying Zhang Xiu-Ling Zhou Yan-Bing Shen Wang Min Yang Zhang

Sep 2026 · Bioresource Technology · pp. 135885 · 0 citations

Medicine

TL;DR

This work demonstrates for the first time that modulation of protein acylation via the MpKat/MpSir regulatory axis is a viable and effective strategy to enhance steroid bioconversion in mycobacteria, offering a new dimension for metabolic engineering beyond conventional pathway optimization.

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