Sep 2026
Enhancing phytosterol tolerance and Repeated-Batch androstenedione production in Mycolicibacterium by modulating global acylation levels.
This work demonstrates for the first time that modulation of protein acylation via the MpKat/MpSir regulatory axis is a viable and effective strategy to enhance steroid bioconversion in mycobacteria, offering a new dimension for metabolic engineering beyond conventional pathway optimization.
Yu-Ying Liu, Yang Huang, Chen-Ying Zhang et al.
· Bioresource Technology · 0 citations