TL;DR
The results suggested that the compounds, 1PB1 and 45R, possessed a dual mode of action involving two cellular targets: CYP51 and exo-β-1,3-glucanase in Candida albicans.
Astragalus , as a traditional tonic herb, has alycosin-7-O-β-D-glucoside as one of its main active components. In this study, a strain of Lactobacillus helveticus HP-B1137 was isolated from raw milk in Mudan District, Heze City, Shandong Province. The probiotic properties, and ability to biotransfor...
Seven novel phenyl-O-β-d-ribofuranoside derivatives (1–7), along with four known naphthalenones (8–11), were isolated from the endophytic fungus Neofusicoccum sp. LZUC-S1 using a bioactivity-guided isolation. Their chemical structures were elucidated through an integrated analysis of IR, NMR, and HRESIMS data, and ve...
Antifungal resistance and invasive fungal infections remain the major therapeutic issues, especially in patients with impaired immune systems. Aspergillus fumigatus is the main cause of invasive aspergillosis and sterol 14-α-demethylase (CYP51B), a key enzyme in the biosynthetic pathway of ergosterol, is an important t...
Ansacarbamitocin B (1) and D (2) were identified as major compounds from ISP-2 agar culture of Amycolatopsis sp. FID23-7-18, isolated from the exoskeleton of Mycetomoellerius mikromelanos worker ants. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy and MS data. Compounds 1 and 2 showed...
The results revealed that An-EtOAcE exhibited broad-spectrum antimicrobial effects, with maximum inhibition against E. coli, and significant α-amylase and α-glucosidase enzyme inhibition in antidiabetic activities with IC90 of 125.90 ± 1.32 and 80.60 ± 2.74 µg/mL, respectively.
A new polyketide, phomporone A, along with three related analogues, cytosporone P, cytosporone Q, and cytosporone E were isolated from the mangrove-derived fungus Phomopsis asparagi ZMU-35-1 and displayed the most potent and broad-spectrum antifungal profile.
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