Pyoluteorin Production Drives the Antimicrobial-Potentiating Activity of Alpaca Oral Microbiota Components

Antimicrobial properties of postbiotics of different LAB against multidrug resistance bacteria

It was shown the comparative antimicrobial activity of postbiotics isolated from lactic acid bacteria (LAB) strains of genus Enterococcus and Lactobacillus against three broad panelsof human pathogens showed strain-specific inhibitory effects, highlighting their narrower antimicrobial spectrum relative to antibiotics.

Silybum marianum against multidrug-resistant bacterial pathogens: mechanisms of action, synergistic therapy, nanoformulations, and clinical translation

Cynaroside targets distinct metabolic pathways in gram-positive and gram-negative pathogenic bacteria: an integrated multi-omics study

The differential antibacterial mechanisms of cynaroside isolated from Turpinia arguta against Gram-positive and Gram-negative bacteria are revealed, laying a theoretical foundation for the development of species-selective natural antibacterial agents.

Postbiotic-mediated antibiofilm activities of newly isolated LAB strains against cariogenic pathogens.

The biocompatibility of neutralized postbiotics in L929 and HGF cell lines is demonstrated, which might be useful for oral applications and indicates the presence of metabolites like biosurfactants that can interfere with surface-pathogen interactions.

Structure-activity relationship and membrane-targeting mechanisms of shikimate-related metabolites against Gram-positive and Gram-negative bacteria.

AIMS The rise of antibiotic-resistant bacteria has intensified the search for novel antimicrobials. In this context, shikimic acid is a versatile scaffold widely used as a precursor to bioactive compounds and drugs. This study screened the antimicrobial activity and underlying mechanism of 18 shikimate-related metaboli...

Bioprospecting Soil Microorganisms as a Source of Antimicrobial Compounds Active Against ESKAPE Pathogens

The escalating global crisis of antimicrobial resistance (AMR), particularly among the ESKAPE group, necessitates the discovery of novel therapeutic agents. Soil ecosystems represent a vast, under‐explored repository of microbial secondary metabolites with potent antimicrobial properties. This study aimed to identi...