Aug 2026· Nature Reviews. Cancer· Vol 26, pp. 830 - 848· 0 citations· 241 references
Medicine
TL;DR
This Roadmap examines current knowledge gaps in risk factors, proposes an integrative conceptual model for risk factor discovery and prevention, and highlights the role of transdisciplinary science and patient engagement in reversing the trend.
This review critically synthesizes recent evidence on EOCRC epidemiology, risk architecture, life-course carcinogenesis, molecular and microbiome-associated mechanisms, diagnostic delay, screening limitations, treatment considerations, and survivorship needs, with the aim of reframing EOCRC as an age-attuned clinical a...
Magda Grześkiewicz-Szostak, K. Gęca, M. Skórzewska· Current Oncology Reports· 0 citations
Observational evidence does not establish that any single factor causes early-onset colorectal cancer or should independently determine screening eligibility, but the findings support prevention throughout the life course with healthier food and activity environments, tobacco control, reduced harmful alcohol use, and b...
A. Alegre-Martínez, L. Cabañas-Alite, I. Fernández-Benet et al.· Cancers· 1 citation
A retrospective secondary analysis of comprehensive genomic and immune profiling data from 1737 patients with colorectal cancer tested showed that tumours arising in patients with EOCRC had lower tumour mutational burden than tumours diagnosed as LOCRC, whereas other immune-related biomarkers did not remain significant...
A. Nogueira, Jennifer Brondon, Konstantin Haradinov et al.· Oncology and Therapy· 0 citations
The global EOPC burden among WCBA and its links to core metabolic determinants are delineated, providing an evidence base to guide targeted interventions in this priority population and support progress toward international development goals.
Jiaxing Li, Jing Luo, Qi-Hui Hu et al.· PLoS ONE· 0 citations
Early-onset cancers (EOCs), defined as cancers diagnosed before the age of 50, are increasing globally. This rise cannot be fully explained by improved detection, suggesting the involvement of evolving environmental and lifestyle-related risk factors. In parallel, the global prevalence of obesity has increased substant...
Mansi Upadhyay, Arianna V. Bastian, T. Cardaci et al.· Carcinogenesis· 0 citations
It is proposed that sporadic microsatellite-stable EOCRC and a subset of PCCRC represent sentinel manifestations of a broader, under-recognised process of exposure-related accelerated carcinogenesis, and postulate that cumulative exposures converge to create biologically permissive tissue states that enable accelerated...
K. Truninger, H. Easwaran, Finlay A. Macrae et al.· Gut· 0 citations
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