The gut microbiome is a modifiable determinant of response to immune checkpoint inhibitors (ICI), positioning antibiotic exposure as a critical yet under-recognized risk factor for worse survival outcomes in immuno-oncology. As nearly 30% of ICI-treated patients receive antibiotics and indications of cancer immunothera...
Serena Porcari, L. Bolte, J. Björk et al.· Cancer Cell· 0 citations
Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Many efforts have been made to stratify CRC cases, from investigating the genomic characteristics of the tumor to – more recently – considering the gut microbiome. Differences in the composition of the gut microbiome occur along...
Gianmarco Piccinno, Paolo Manghi, Luca Lazzari et al.· Scientific Reports· 0 citations
This Roadmap examines current knowledge gaps in risk factors, proposes an integrative conceptual model for risk factor discovery and prevention, and highlights the role of transdisciplinary science and patient engagement in reversing the trend.
Ruiyi Tian, Sina Azadnajafabad, E. Waters et al.· Nature Reviews. Cancer· 0 citations
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