Open access
CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults
C. Lisgaras
Tovia Jacobs
L. Figueredo
Elizabeth Pirraglia
Caleb H. Radtke
Jonah N. Keller
N. Karvelas
J. Bernal
Joaquin Ruiz
H. Zetterberg
L. Glodzik
M. D. de Leon
L. B. McIntire
A. Boutajangout
Thomas Wisniewski
Jaime Ramos-Cejudo
D. Alcolea
S. Giménez
J. Fortea
K. Akassoglou
Fanny M. Elahi
Ricardo S. Osorio
Medicine
Abstract
Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer's disease (AD). Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau progression in cognitively unimpaired (CU) individuals remains unknown.