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CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults

C. Lisgaras Tovia Jacobs L. Figueredo E. Pirraglia Caleb H. Radtke Jonah N. Keller N. Karvelas J. Bernal Joaquin Ruiz H. Zetterberg L. Glodzik M. D. de Leon L. B. McIntire A. Boutajangout Thomas Wisniewski Jaime Ramos-Cejudo D. Alcolea S. Giménez J. Fortea K. Akassoglou F. Elahi Ricardo S. Osorio

Aug 2026 · Alzheimer's & Dementia · Vol 22 · 0 citations · 55 references

Medicine

TL;DR

Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau progression in cognitively unimpaired (CU) individuals remains unknown.

Abstract

Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer's disease (AD). Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau progression in cognitively unimpaired (CU) individuals remains unknown.

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