Author

D. Alcolea

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Open access Aug 2026

CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults

Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer's disease (AD). Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau progression in cognitively unimpaired (CU) individuals remains unknown.

C. Lisgaras, Tovia Jacobs, L. Figueredo et al. · Alzheimer's & Dementia · 0 citations

Open access Jul 2026

CSF and plasma tau biomarkers in the Down syndrome–Alzheimer’s disease continuum

These findings highlight the complementary roles of CSF and plasma tau biomarkers in tracking disease progression: CSF biomarkers capture early pathological changes, whereas plasma biomarkers more effectively reflect disease progression within symptomatic stages.

J. Arranz, J. Lantero-Rodríguez, Luisa Sophie Braun-Wohlfahrt et al. · EBioMedicine · 1 citation