AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
WNK4 acts as an immune-relevant suppressor in endometrial cancer, partly by limiting M2-like polarization and weakening macrophage-driven tumor support, partly by limiting M2-like polarization and weakening macrophage-driven tumor support.
Thrombospondin 1 regulates pathological interorgan communication between GC cells and the peritoneal niche by targeting TAMs through metabolic reprogramming, thereby providing a potential therapeutic target for GC with PM and insights into interorgan metastasis mechanisms.
Integrated multi-omics analyses and functional experiments demonstrate that UNC93B1 promotes IL-6/STAT3-dependent tumor–macrophage communication, thereby enhancing M2-like macrophage polarization, EMT activation, and invasive tumor behavior.
The macrophage/endothelial-derived APP-CD74 axis promotes OS progression by activating tumor-associated signaling and remodeling the immune microenvironment by activating tumor-associated signaling and remodeling the immune microenvironment.
The PLK1/FOXM1-associated tumor-cell state may represent a distinct molecular feature associated with proliferative activity, invasive phenotypes, and macrophage-related immune features in EC and is highlighted in potential therapeutic directions for future investigation.
This work reveals that POSTN + CAFs establish an immunosuppressive TME and are associated with ICB non-response in GC by remodeling lipid metabolism through the ITGB1-PI3K/AKT/mTOR-PPARγ axis, a finding that underscores the therapeutic value of intervening in this specific CAF-macrophage metabolic crosstalk.
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