Open access

APOBEC3G Splicing Defects in Nonhuman Primate Models Result in Disparate Viral Mutational Profiles Relative to Humans

A. Mendez Rachael Springman-Rodriguez Ayub Bokani Fiona Carter-Tod N. Haghjoo Margarita Rzhetskaya Colin Rorex Jake D. Lehle Mohadeseh Soleimanpour Luis Ferrández-Peral Hanjing Yang Michael A. Carpenter Rajesh Thippeshappa S. Kutluay Richard N. McLaughlin Mahesh Mohan Binhua Ling L. Giavedoni M. Rodriguez-Barradas R. Harris Xiaojiang S. Chen Susan T. Weintraub J. Hultquist D. Ebrahimi

Aug 2026 · bioRxiv · 0 citations

Biology Medicine

TL;DR

It is reported that APOBEC3G (A3G), a potent antiviral restriction factor and the major source of genetic variations in HIV, exhibits a widespread mRNA splicing defect in the Cercopithecinae subfamily, which includes the commonly used NHP models.

DOI PubMed Semantic Scholar

Read PDF

Similar papers

Open access Aug 2026

Genetic innovation in coronaviruses driven by a viral nuclease

It is shown that non-structural protein-15 (NSP15), a nuclease encoded by coronaviruses, can drive the acquisition of a class of insertion mutations, and numerous examples of potential furin cleavage site acquisition and replacement through insertion mutation during the normal course of coronavirus replication are foun...

C. Bianco, Alex C. Stabell, Manivel Lodha et al. · bioRxiv · 0 citations

Open access Sep 2026

A859L Plays a Critical Role in Facilitating Efficient African Swine Fever Virus Replication

African swine fever virus (ASFV) is a highly pathogenic agent that poses a severe threat to the global swine industry. The biological function of A859L, an ASFV-encoded RNA helicase, remains largely elusive. Here, we show that A859L is highly conserved across diverse ASFV isolates and belongs to the SF2 superfamily of...

Xiang-Tao Zhu, Hong-Yu Yan, Wan-Hui Zhou et al. · Viruses · 0 citations

Open access Oct 2026

Natural variation in BtSARSr-CoV nsp12 harbors adaptive mutations that enhance viral replication and spillover risk in humans

ABSTRACT The non-structural protein 12 (nsp12) is essential for SARS-related coronavirus (SARSr-CoV) replication and a major antiviral target, yet the functional significance of its natural variation in bat reservoirs remains unclear. Here, by analyzing 183 bat SARS-related coronavirus nsp12 sequences, we identified mu...

Ang Li, Hao-Rui Si, Ke Wu et al. · Journal of Virology · 0 citations

Open access Sep 2026

Fixed Nonsynonymous vOka Vaccine Mutations in IE62 drive Varicella-Zoster Virus Attenuation in Human Skin

The live, attenuated vaccine for Varicella-Zoster Virus (VZV) protects against chickenpox in children and adults. However, the vaccine strain Oka (vOka) establishes latency and may reactivate. The molecular basis of vOka attenuation remains unknown. We investigated whether three high-frequency single-nucleotide polymor...

Reuben O. Onwe, Joao Ferreira, M. Lloyd et al. · bioRxiv · 0 citations

Open access Sep 2026

Deconvolution of HIV-1 Mutational Signatures Reveals Dominant and Donor-Specific APOBEC3-Associated Mutagenesis Across Anatomical Compartments

HIV-1 persists across multiple anatomical compartments, yet the mutational processes shaping viral diversity within these reservoirs remain incompletely understood. We investigated HIV-1 mutational signatures across blood, spleen, gut, and brain tissues from 21 people with HIV enrolled in the Last Gift rapid autopsy pr...

Mohadeseh Soleimanpour, N. Haghjoo, Jake D. Lehle et al. · bioRxiv · 0 citations

Open access Oct 2026

Polyamine depletion inhibits murine and human norovirus infection

ABSTRACT Noroviruses are non-enveloped, positive-sense RNA viruses in the family Caliciviridae. Human noroviruses (HNoVs) are the leading cause of viral gastrointestinal disease. Despite their clinical relevance, therapeutic strategies for norovirus infections remain limited, partly due to challenges in cultivating HNo...

Maryna Chaika, Heike Laschin, М. М. Пекелис et al. · mBio · 0 citations