Aug 2026· Molecular diversity· 0 citations· 50 references
Medicine
TL;DR
Findings indicate that H7 could serve as a lead compound for the development of novel fungicides against kiwifruit soft rot and preliminary mechanistic investigations suggested that the antifungal activity of H7 is associated with disruption of cell membrane integrity and inhibition of succinate dehydrogenase activity.
BACKGROUND
The persistent proliferation of bacterial phytopathogens presents a significant threat to global food security and agricultural sustainability. Among these pathogens, species belonging to the genus Xanthomonas are particularly destructive. Xanthomonas oryzae pv. oryzae (Xoo), the causal agent of bacterial le...
Yu-Guo Zheng, Mei-Hang Chen, Hua Sun et al.· Pest Management Science· 0 citations
In vivo antifungal assays conducted on rice leaves and kiwifruit demonstrated that X4 displayed satisfactory protective and curative effects, and molecular docking experiments combined with SDH activity assays indicated that X4 engages in favorable interactions with SDH.
Xiao-Yan Pan, Dan Shen, Han Yang et al.· Journal of Agricultural and...· 0 citations
Plant pathogenic fungi pose a serious threat to global agricultural production. Traditional fungicides have become increasingly prominent due to multi-drug resistance. It is urgent to develop new and efficient fungicides with unique mechanisms of action that can effectively overcome drug resistance.
The...
Wen-Jie Hu, Jing-Yi Yu, Xue-Bin Zhang et al.· Chemical and Biological Tech...· 0 citations
In this study, a series of furan amide derivatives were designed and synthesized from natural furan carboxylic acids as starting materials, with the aim of developing potential succinate dehydrogenase (SDH) inhibitors. The antifungal activities of the target compounds against four species of plant‐pathogenic fungi were...
Hong-Xin Luo, Yu-Sen Wang, Yan-Chang Shi et al.· Chemistry and Biodiversity· 0 citations
To discover novel green antifungal candidates, 20 3‐acylaminoisoquinoline derivatives were designed and synthesized by introducing the active fragment phenoxypyridine. Their structures were verified by 1H NMR, 13C NMR, and HRMS. The structure of compound X9 was further confirmed via X‐ray crystallography. Their antifun...
Jia-Yao Zhang, Shuai-Peng Sun, Ya-Jing Guo et al.· Chemistry and Biodiversity· 0 citations
The development of potent synthetic antifungal agents for plants is an ongoing challenge of modern chemistry that impacts biological, medicinal and environmental sciences. Herein, a concise Structure–Activity Relationship (SAR) model involving seven synthetic azidopyrazoles toward three pathogens of agricultural prod...
Daniel Canseco-González, R. Sánchez-Fernández, E. Navarro-Cerón et al.· ACS Omega· 0 citations
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