2026· Methods in Enzymology· Vol 734, pp.
235-268
· 0 citations
Medicine
TL;DR
DNA methylation represents a promising avenue for understanding the biological underpinnings of PND and developing robust biomarkers for risk prediction and personalized care, and integrating genetic, epigenetic, and environmental data through multi-omics approaches may enhance predictive accuracy and improve early intervention strategies.
Machine learning-enabled analysis of CpG methylation profiles revealed robust epigenetic biomarkers of depression that support the development of non-invasive, methylation-based screening tools and provide insight into the molecular underpinnings of adolescent depression.
E. Lax, R. Avneri, A. Pinhasov et al.· International Journal of Neu...· 0 citations
Preliminary evidence of DNA methylation signatures linked to potential candidate genes and biological pathways that may be relevant to ADS are provided, supporting the need for validation in larger independent cohorts and functional experimental studies.
C. Thirumoorthy, Sree Sankar Darveekran Nair, M. Deepa et al.· Neurochemistry International· 0 citations
This study provides compelling evidence of distinct DNA methylation signatures associated with ELS-induced MDD and MDD without ELS exposure, highlighting the complex interplay between genetic and environmental factors in the etiology of this complex disorder.
Y. Dwivedi· International Journal of Neu...· 0 citations
The integration analysis showed that genetic variants and DNA methylation at sites annotated to the FADS gene cluster were linked with lipid species that were also associated with lifetime MDD status, while introducing DNA methylation as an additional molecular layer supporting this link.
H. Smith, A. Richmond, M. Adams et al.· medRxiv· 0 citations
This exploratory two-stage epigenetic study suggests that ADCY2 promoter hypomethylation in peripheral buccal epithelial DNA is associated with core symptom dimensions of adolescent BPD.
Qian Xiao, Li-Ying Shen, Lin Wang et al.· Psychiatry Research· 0 citations
It is suggested that CRS-induced DNA hypermethylation at CG and CHH sites in the female mPFC may contribute to stress-induced transcriptional dysregulation, potentially driving anxiodepressive-like behaviors.
Ming-Lian Luo, Yi-Heng Li, Yuan-Jian Yang et al.· Stress· 0 citations
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