HPLC-PDA-MS/MS Profiling, In Vitro and In Vivo Evaluation of Melilotus indicus Stem Extract: Insights Into its Antioxidant and Hepatoprotective Mechanisms for Potential Therapeutic Applications

Ibtissem Nafti A. Feriani Nihad Sahri M. Tir E. Saadaoui W. Elfalleh H. Bendif Shakilur Rahman Mansour Sobeh Nizar Tlili

Aug 2026 · Journal of Pharmaceutical Innovation · Vol 22 · 0 citations · 67 references

TL;DR

Findings demonstrate that M. indicus stem extract contains a rich array of bioactive molecules with potent biological activities, highlighting its promise as a natural source of biomolecules for preventing oxidative stress–induced liver damage and its potential application in phytotherapy.

DOI Semantic Scholar

View source

Similar papers

Open access Sep 2026

Phytochemical Characterization and Integrated Biological Evaluation of Baccharis dracunculifolia DC Ethanol Extract: Antioxidant, Anti-Inflammatory and Toxicological Evidence

Background/Objectives: Baccharis dracunculifolia DC. is a medicinal plant and the primary botanical source of Brazilian green propolis. This study aimed to characterize the phytochemical profile of its ethanol extract and evaluate its antioxidant, anti-inflammatory, cytotoxic, and acute oral toxicity profiles. Methods:...

G. R. da Silva, Lucas Pires Guarnier, Arianne Jung Kluck et al. · Pharmaceuticals · 0 citations

Open access Oct 2026

Phytochemical profiling and biological evaluation of Duranta serratifolia (Griseb.) Kuntze cultivated in Egypt: HPLC and lC-mS characterization, antimicrobial and anticancer activities, and in silico validation.

The present study provides a phytochemical and biological evaluation of Duranta serratifolia (Griseb.) Kuntze cultivated in Egypt. Preliminary screening revealed the predominance of flavonoids and phenolic compounds, which was supported by high total phenolic (101.6 mg ± 2.1 GAE/g) and flavonoid (166.3 ± 1.1 mg QuE/g)...

A. Mahmoud, Mona M. Eid, Fatma S. Mahrous et al. · Natural Product Research · 0 citations

Oct 2026

Phyto-Metabolomic Insights Into Ficus hispida Linn.: Antioxidant Activity, Polyphenolic Content, and Antidiabetic Marker Discovery via LC-ESI-Orbitrap-MS/MS and GC-QqQ-MS/MS.

The wild edible fruit Ficus hispida Linn (F. hispida), traditionally used for diabetes management, remains unexplored with respect to bioactive constituents and underlying mechanisms. Therefore, this study investigated the antidiabetic potential of F. hispida fruits through comprehensive phyto-metabolomic profiling int...

Kotla Kotesh, Efficiency Myrsing, Tejaswini Chandrakant Patil et al. · Journal of Food Science · 0 citations

Open access Sep 2026

Bioassay-Guided Evaluation and LC-MS/MS Characterization of Five Limonia acidissima L. Plant Parts: A Multitarget Approach Against Acne Vulgaris

Findings support the potential of L. acidissima leaf extract as a promising multitarget anti-acne candidate and suggest favorable drug-likeness and skin-permeation profiles.

I. M. Kusuma, B. Elya, H. Suryadi et al. · Molecules · 0 citations

Open access Aug 2026

GC–MS Profiling of Bioactive Compounds from Oxalis latifolia Leaves: Integrated in silico and in vitro Evaluation of Antidiabetic Potential

The data collectively suggest that Oxalis latifolia exhibits significant antidiabetic activities, underscoring its potential as a natural resource for future pharmacological research.

Sreedhar Sreeja P., Neethu · Research journal of chemistr... · 0 citations

Open access Sep 2026

UPLC-MS metabolite profiling and antioxidant efficacy of Neopestalotiopsisclavispora isolated from Oroxylum indicum (L.) Kurz Stem Bark

Results suggest N.clavispora may have antioxidant related activity under the conditions tested, supporting further in vitro and in vivo studies.

Sushma Swaroopa, Amshumala Bhoothakallu Lolajaksha, T. Gnanasekaran et al. · PLoS ONE · 0 citations