Results implicate TNIK in the mechanisms linking epithelial-mesenchymal plasticity with proliferation and evasion of senescence and provide insights into future strategies for the clinical deployment of TNIK inhibitors in LUSC and other TNIK-dependent malignancies.
These findings identify CELSR2 as a previously unknown regulator of epithelial-mesenchymal plasticity and reveal that heterogeneous CELSR2 expression shapes spatially and functionally distinct tumor cell populations, thereby contributing to intratumoral heterogeneity in TNBC.
Julia Koren, Nour-Islem Yanis Saidani, Abdessamad Elkaoutari et al.· bioRxiv· 0 citations
This study identifies TXNRD1 as a crucial regulator of cellular plasticity and metastasis in NSCLC via the TGF-β1 pathway, suggesting that targeting TXNRD1 may reduce metastatic potential and improve patient survival.
Yaw-Dong Lang, Shin-Yuan Gu, Jou-Ho Shih et al.· Cancer Biology & Therapy· 0 citations
Lung squamous cell carcinoma (LUSC) is associated with limited therapeutic options and poor clinical prognosis. The Octamer nucleotide--binding transcription factor (NONO), which lacks the POU domain, is implicated in nearly every aspect of gene regulation. It participates in various biological processes including cell...
Jin-Long Huang, Li-Ping Zhu, Wei-Qing Zhang et al.· Frontiers in Oncology· 0 citations
ABSTRACT Hepatocellular carcinoma (HCC) remains a global health challenge due to its high metastatic potential and poor prognosis. This study investigated the role and underlying molecular mechanisms of N-acetyltransferase 10 (NAT10)-mediated α-tubulin acetylation in HCC progression. Using Huh-7 and SNU-449 cell lines,...
Reduced TET1 expression was observed in SCC-restricted public cohorts, while TET1 depletion promoted malignant phenotypes in HeLa cells, which identifies a candidate signaling association that warrants validation through rescue experiments and locus-specific epigenetic studies.
Yang Liu, Lu-Jia Liu, Lu-Sheng Wang et al.· Frontiers in Oncology· 0 citations
It is demonstrated that IL-13Rα2 is a crucial, context-dependent signaling receptor that maintains the p-EMT state and malignant progression via the STAT6 axis, making it a precise therapeutic target for advanced, phenotypically plastic colorectal cancer.
Jian Lu, Marko Kornmann, B. Traub· Molecular and Cellular Bioch...· 1 citation
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