protein folding

Reduction in land area devoted to agriculture from a hypothetical universal vegan diet in Canada

This paper estimates the savings in agricultural land area that would occur in Canada if all domestically-produced and consumed animal food products (AFPs) and fish were replaced with domestically-produced high-protein plant food products (PFPs), accompanied by increases in consumption of domestically-produced fruits a...

Reveal the diagnostic value of a neutrophil inflammation- and cell death-associated gene signature in rheumatoid arthritis

This study aimed to construct an artificial neural network (ANN) diagnostic model for rheumatoid arthritis (RA) based on a neutrophil inflammation- and cell death-associated gene signature derived from a previously reported neutrophil extracellular traps (NETs)-related gene set, and to explore its association with immu...

Second-Generation AOH1996 Analogues with Enhanced Pharmacological Properties for Targeting PCNA

Second-generation AOH analogues with enhanced pharmacological properties were created through scaffold optimization, and both compounds induced robust G2/M arrest at lower concentrations than the parent molecule and significantly enhanced transcription–replication conflicts in pancreatic cancer cells.

The CCT6A paradigm: biomarker potential and therapeutic challenges in oncology and beyond

Advances in PMP22 sequence variant-associated hereditary neuropathy with liability to pressure palsies: from gene dosage effects to mechanism-informed variant interpretation

Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant neuropathy classically caused by a heterozygous deletion of the 17p11.2-p12 region encompassing PMP22. However, PMP22 sequence variants can produce HNPP-like or overlapping phenotypes, complicating variant interpretation. This narr...

Quantification of Folded Protein in Infant Formula and Through Processing Steps

Bioinformatics tools for protein modeling in cancer

Bioinformatics tools for protein modeling in neurodegenerative diseases

The credentials for Ribonuclease A to be catalytically active: The prerequisite of oxidative protein folding

Enzymatic routes to site-specific protein-nucleic acid conjugates

Nature rarely joins nucleic acids to proteins covalently, yet synthetic protein-nucleic acid conjugates enable diverse applications from nanotechnology to therapeutics, which require or benefit from defined, stable, one-to-one linkages of known geometry. Here I evaluate biochemical routes to such conjugates against fou...

A Robust DIA-Based Platform for Large-Scale Plasma Glycoproteomics and Biomarker Discovery

Structural changes in protein glycosylation are recognized as phenotypes in numerous diseases, including cancer. Despite the promise of glycoproteomics for diagnostic biomarker discovery, large-scale studies remain limited by challenges in reproducibility, throughput, and quantitative precision. Here, we present a ro...

Hepato- and Immunoprotective Dynamics of Standardised Andrographis paniculata Extract in a Murine Polymicrobial Sepsis Model

Background: Sepsis-associated liver injury drives mortality in polymicrobial sepsis yet lacks targeted adjunctive therapy. Andrographis paniculata (Burm. f.) Nees, known in Indonesia as sambiloto, yields andrographolide, a diterpene lactone that suppresses nuclear factor kappa B (NF-κB) and activates nuclear factor ery...