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1,959 papers
Reward maximization alignment methods for discrete diffusion models have primarily focused on steering the reverse process, either by influencing token logits or by selecting favorable sequences at intermediate steps. These approaches largely treat inference as a unidirectional process, lacking mechanisms for revisitin...
This study explored the effects of micro-nano bubble (MNB) pretreatment combined with Lactiplantibacillus plantarum (Lp) fermentation or lipase (Lip) hydrolysis on lamb meat quality, gel properties, and flavor. SEM revealed that MNB loosened muscle fibers and increased porosity, while FT-IR indicated that MNB alone did...
This proposal builds upon the foundation established in BAG MX 2521 and MX 2644 and represents a collaborative effort among prominent Swiss academic institutions, including EPFL, UNIL, UNIGE, university of Zurich and SLS. Under the leadership of Dr. Florence Pojer, the head of the Protein Production and Structure core...
In this study, we assessed the effects of a non-linear cold stress experiment on the physiology and metabolite profiles of the emerging sea anemone model system Aiptasia couchii. This repository hosts Supplementary Tables S1-S7 along with Supplementary Files S1-S4 which contain R scripts used for the analyses. Manuscri...
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The results reveal a new C-terminus-mediated RPA-RecQ interaction in L. donovani that resembles the prokaryotic SSB-RecQ interaction mechanism, while maintaining functional conservation of eukaryotic DNA metabolism.
Metata Ayib is a traditional Ethiopian spiced fermented hard cheese produced through spontaneous anaerobic fermentation of cottage cheese ( Ayib ) with various spices. This critical review, the first comprehensive synthesis of research on Metata Ayib , critically evaluates the available literature to assess it...
In this study, we assessed the effects of a non-linear cold stress experiment on the physiology and metabolite profiles of the emerging sea anemone model system Aiptasia couchii. This repository hosts Supplementary Tables S1-S7 along with R scripts used for the analyses. Manuscript status: accepted for publication in M...
An enhanced CgCas12n system (eCgCas12n) is established that enables efficient mammalian genome editing and provides an efficient genome- and base-editing platform for functional genetic studies.
Lead poisoning remains a persistent global health challenge. Current small-molecule chelation therapies for lead poisoning cause systemic side effects due to non-specific metal depletion. Here, we propose an "affinity-selectivity-safety" strategy using a living biointerface in which the probiotic is programmed to overe...
Reliable screening and discrimination between multifloral and monofloral honeys are important for supporting honey quality assessment, consumer confidence, and market transparency. In this study, the potential of physicochemical parameters combined with machine learning techniques was investigated for the binary clas...
This work explored how the guide RNA of CRISPR genome editing system folds and modulates its structural flexibility to carry out the roles required for each assembly state from its unbound apo form to the functional Cas9 RNP state for target DNA cleavage using ABEL-FRET spectroscopy.
By phi‑modulating the 240 E8 root vectors at the 132 Hz base frequency, the lattice self‑organizes into nested 120‑cell and 600‑cell sub‑lattices whose scaling ratios follow the golden ratio. This harmonic collapse generates a self‑similar energy cascade that maps directly onto the torsion angle distribution of DNA, li...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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