Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving mutations in the
SOD1
and
TARDBP
genes that significantly influence its development. Nonsynonymous SNPs in these genes can disrupt protein stability, folding, and regulatory functions, leading to the loss of motor neurons....
It can be concluded that both the promoter fragments of ELOVL2 are capable of regulating gene expression even in a cell culture system with the larger fragment being more effective.
Jakkoju Theja Sri, D. Sakaram, Samala Sai Sagar Reddy et al.· Journal of Advances in Biolo...· 0 citations
In this exploratory analysis, SIBS is associated with clinical severity and myocardial stress in AMI patients and a composite model combining SIBS, GRACE score, and hs-CRP improves identification of elevated myocardial stress compared with single biomarkers in this exploratory analysis.
Li-Yun Peng, Wen-Ji Lin, Meng-Jia Wang et al.· Frontiers in Cardiovascular...· 0 citations
This work introduces a symmetric dual-path architecture that both leverages PLMs for pretrained sequence evolution knowledge and MPLMs for pretrained structural knowledge to iteratively guide protein sequence generation.
Han-Dong Wang, Jiaxin Qi, Baisheng Lai et al.· 0 citations
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It is demonstrated that BcNCED3 positively regulates thermotolerance in non-heading Chinese cabbage and provide a genetic resource for heat-tolerance breeding.
Wen-Jun Lu, Chang-Wei Zhang, Zhao-Kun Liu et al.· Plants· 0 citations
The Dynamic Protein Structure Paradox is defined as the apparent conflict between structural accuracy and functional underdetermination and DPSP is developed as an integrative evidentiary assessment framework rather than a new theory or paradigm.
The RF model based on six readily available laboratory parameters accurately predicts 30-day mortality in septic shock patients, however, the findings are limited by the single-center retrospective design and lack of external validation, warranting further multi-center studies to confirm generalizability.
Shan-Bi Chang, Yue-Bang Wang, Zi-Jin Zhang et al.· Frontiers in Microbiology· 0 citations
It is suggested that spatial stiffness heterogeneity, rather than stiffening alone, contributes to predicted curvature localization in skin surrogate bilayers and may provide a mechanics-based readout for evaluating prospective cosmetic interventions.
Yiwen Li, Feng Cao, Qian-Wen Fan et al.· Cosmetics· 0 citations
The first validated liquid chromatography tandem mass spectrometry (LC-MS/MS) bioanalytical method for the quantification of atirmociclib in mouse plasma is reported, validated in compliance with international council for harmonisation-M10 (ICH-M10) guidelines.
Ashwani Gaur, U. Patel, Ashutosh Gavali et al.· Journal of chromatography. B...· 0 citations
The signaling pathways that regulate cellular redox homeostasis, the cellular waste disposal system, ER stress and autophagy are major signaling pathways involved in aSMCs’ responses to uremic serum exposure, which may contribute to the severe arterial-specific clinical symptoms observed in CKD/ESKD patients.
You-You Zheng, Kent A. Lee, U. Uriyanghai et al.· Biomolecules· 0 citations
Structural prediction and coimmunoprecipitation indicate that the compound variants may be associated with the development of MSS by weakening SIL1-BiP binding, and preliminary functional evidence that the identified variants may affect SIL1 abundance and SIL1-BiP interaction, supporting their relevance to the MSS phen...
Findings support DepPrior as a reproducibility-oriented, hypothesis-generating approach for target nomination for lung adenocarcinoma targets by requiring concordant evidence of CRISPR dependency separability, molecular predictability, and cross-cohort expression/protein reproducibility.
Feng-Fei Zhou, Cheng Wang, Lizhi Mo et al.· Frontiers in Pharmacology· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
