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2,039 papers
A phosphorylation-triggered order-to-disorder transition that relieves FOXM1 autoinhibition and highlight Ser715 as a key structural and energetic switch is supported and provided a dynamic molecular framework for targeting FOXM1 activation via its regulatory fold.
The catalytic mechanism of GHKL ATPases is refined and variants of uncertain significance in these DNA mismatch repair proteins substantially reduced the ATPase activity, indicating functional impairment, and a structural and functional framework for interpreting disease-associated variants in GHKL ATPases is provided.
Investigating the physiological responses of the invasive Mediterranean mussel to osmotic stress by studying two populations in Los Angeles County, CA with contrasting hydrology highlights that local environmental histories shape physiological resilience, which will dictate how marine bivalves cope with future climate-...
Objective Heat-induced stress (HS) amid global warming compromise cattle reproductive performance causing economic loss including the vulnerable Korean native beef cattle, Hanwoo. Nevertheless, knowledge of response and effect in cattle oviduct epithelial cells (OEC) under HS remains lacking due to restricted commercia...
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New insights are provided into the physiological mechanisms of host adaptation in spider mites and the carboxylesterase gene TtCarE-4 is identified as a potential RNAi target for sustainable pest management.
A substantial number of deleterious variants involved glycine substitutions, which are likely to affect protein flexibility, folding, and intermolecular interactions, potentially impairing the structural integrity of the glomerular basement membrane.
Established genomic and population-level evidence support a Likely Pathogenic, loss-of-function classification for the TTN p.Arg3936Ter variant, which introduces a premature termination codon predicted to generate a truncated titin protein of 3,935 amino acids and is predicted to escape nonsense-mediated decay.
Dynamical Topology Optimization (DTO) provides a framework for optimizing complex network topologies by iteratively refining connections based on emergent properties. This paper introduces a novel algorithm, termed 'Adaptive Topology Evolution', which integrates reinforcement learning and graph theory to achieve automa...
Motivation: Convergent evolution produces enzymes with different folds but identical catalytic mechanisms, yet no method reliably detects shared catalytic sites across non-homologous proteins. Dedicated catalytic site tools achieve recall below 4%, and general-purpose aligners sacrifice local catalytic geometry for glo...
Motivation: Convergent evolution produces enzymes with different folds but identical catalytic mechanisms, yet no method reliably detects shared catalytic sites across non-homologous proteins. Dedicated catalytic site tools achieve recall below 4%, and general-purpose aligners sacrifice local catalytic geometry for glo...
The immunomodulatory effect of E. menziesii safely regulates macrophage behavior, IL-1β and IL-6 release and promotes scratch area reduction and could be linked to the presence of sulfate polysaccharides and mannitol.
ESMCHalo is a frozen protein-sequence predictor that combines ESMC-600M layer-36 canonical mean representations with five compact student heads trained using leakage-free out-of-fold knowledge distillation. The release provides frozen inference code, model checkpoints, calibration, a fixed threshold, verification utili...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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