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[This corrects the article DOI: 10.3389/fcimb.2026.1835140.].
The escalating crisis of multi-drug resistant (MDR) Klebsiella pneumoniae (KP) renders standard antibiotic treatments increasingly ineffective, necessitating a shift toward alternative approaches like vaccination. However, the development of a broadly protective vaccine remains hindered by the pathogen's extensive sero...
Serum amyloid A (SAA) is an acute-phase protein that can increase in plasma concentration by up to 1000-fold during infection and inflammation. Clinical studies have identified significantly elevated SAA levels in Mycoplasma pneumoniae pneumonia (MPP), correlating with disease severity, lung injury, and prognosis....
Aptamer-functionalized liposomes are a promising strategy to improve the selectivity of anticancer therapies. AT11-L2 is a G-quadruplex (G4)-forming aptamer with high affinity for nucleolin (NCL), which is overexpressed at the surface of non-small cell lung cancer (NSCLC) cells. Here, we developed AT11-L2-functionalize...
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Chapter IV Explainable AI for end-to-end target discovery and molecular design in plant pathogenic fungi Supplementary file S1 - Per-fold cross-validation metrics for APEX-Tar and APEX-Drug across all GNN architectures and baselines Supplementary file S2 - Cross-organism generalization of APEX-Drug: predictions on 228...
Chapter IV Explainable AI for end-to-end target discovery and molecular design in plant pathogenic fungi Supplementary file S1 - Per-fold cross-validation metrics for APEX-Tar and APEX-Drug across all GNN architectures and baselines Supplementary file S2 - Cross-organism generalization of APEX-Drug: predictions on 228...
Climate change is expected to affect terrestrial ectotherms worldwide, including land snails, which are often characterized by limited dispersal capacity and high sensitivity to environmental fluctuations. Heat shock proteins of the 70 kDa family (HSP70) are highly conserved molecular chaperones involved in protein f...
A unified physics‑based framework for macromolecular refinement , Predictor and mutational scanning. Built around a novel Self‑Organised Criticality (SOC) controller, it refines proteins, DNA, RNA, and their complexes using a fully differentiable energy function powered by OpenMM, then scales to thousands of in silico...
The RNase-H fold is an ancient protein fold found in diverse nucleases that is characterised by a conserved structural core (five β strands and ⍺ helices), canonical DDE/D catalytic residues and catalytic mechanism. This study focuses on the evolutionary conservation of the RNaseH-like domain in the transposase-derived...
Nanomedicines that perform well in conventional cell cultures often fail to translate into patients, in part due to the inability to reproduce the protein corona, and hence the biological identity, that nanoparticles acquire within the tumor microenvironment (TME). Here, we establish patient-derived colonic organoids (...
The escalating crisis of multi-drug resistant (MDR) Klebsiella pneumoniae (KP) renders standard antibiotic treatments increasingly ineffective, necessitating a shift toward alternative approaches like vaccination. However, the development of a broadly protective vaccine remains hindered by the pathogen's extensive sero...
Achromatium spp. are giant bacteria harboring hundreds of non-clonal chromosomes per cell. The allelic divergence they exhibit could be a mechanism to enable fine-tuned responses to environmental changes, enabling this organism to broaden its ecological range. However, while ubiquitous in freshwater and marine environm...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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