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1,407 papers
The synthesis highlights the importance of combining established breeding methods with emerging genomic and biotechnological approaches while conserving wild accessions and landraces.
CAF-directed stromal priming as a strategy to enhance chemoimmunotherapy and warrant evaluation in randomized studies with integrated biomarker analyses are supported.
A residue-resolved prioritization platform for covalent cancer drug discovery. CanProTarget integrates cancer gene dependencies, small-molecule covalent ligand engagement measured by chemoproteomics, and base-editing evidence for individual cysteines, keeping each layer at the resolution it is measured at.
Findings identify SFRP2 as a key regulator of PDAC progression and support the development of SFRP2-targeted therapies as a novel treatment strategy for pancreatic cancer.
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This review systematically summarizes the key improvements and evolutionary progress in the prime editor design and its updated delivery systems, with a particular focus on innovative modifications that have successfully overcome technical barriers.
Using CRISPR-Cas9 gene editing in human pluripotent stem cells, HOPX is identified as an important regulator of oRG-like cell maintenance and the neurogenic-gliogenic balance, providing insight into the molecular programs governing human neural progenitor expansion.
UnZipro is presented, an efficient, scalable, and generalizable framework for zero-shot, in silico protein evolution, that integrates a compact, pre-trained inverse folding model with meta-learning to derive family-specific fitness landscapes.
This study provides high-quality mitogenome assemblies for P. calleryana and P. betulifolia, revealing coexisting structural variations and highly conserved sequences, and thereby offers a significant genetic resource for the Rosaceae family that will facilitate further investigations into the molecular diversity and g...
It is demonstrated that co-inactivation of HSD17B11 followed by PAC selection can be used to rapidly identify efficient guide RNAs targeting a gene of interest and to readily isolate clones inactivated for one or multiple genes.
A Python script that draws tRNA cloverleaf secondary-structure diagrams from tRNAscan-SE output. Every structure is drawn on the same fixed template: acceptor stem up, D-arm left, anticodon arm down and T-arm right, with the anticodon highlighted and a 3′-CCA appended. Base pairs, stem and loop lengths, and anticodon p...
Although recent studies suggest the dysbiosis of gut microbiome in multiple system atrophy (MSA), particularly a decrease in Akkermansia muciniphila, as a contributor to dysfunctional intestinal barrier and alpha-synuclein spreading to the brain, new methods, including fecal RT-QuIC, smell testing, microbiota replac...
A Python script that draws tRNA cloverleaf secondary-structure diagrams from tRNAscan-SE output. Every structure is drawn on the same fixed template: acceptor stem up, D-arm left, anticodon arm down and T-arm right, with the anticodon highlighted and a 3′-CCA appended. Base pairs, stem and loop lengths, and anticodon p...
GPT-Lab
· gpt-lab.eu
Oct 8, 2026
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
A Blog post by Ai2 on Hugging Face
A Blog post by ServiceNow-AI on Hugging Face
“InstructMesh” can generate designs for everyday objects that are easy to edit and fabricate for both experts and newcomers to 3D modeling.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
Algorithms & Theory
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