The ethics of germline gene editing are discussed in this Viewpoint regarding 3 applications: basic science, treatment and prevention, and enhancement.
MicroRNA (miRNA) genes are frequently located in close proximity within the genome, forming so-called clusters. These clusters are transcribed as polycistronic units, suggesting coordinated transcriptional regulation of the miRNAs they contain. However, individual mature miRNAs from the same cluster often accumulate at...
Diana V. Maltseva, Alexander Tonevitsky· Frontiers in Molecular Biosc...· 0 citations
For more than four decades, islet encapsulation has been defined by a single objective: to immunoprotect transplanted cells while preserving glucose sensing and insulin delivery, thereby eliminating systemic immunosuppression. No passive device has yet achieved that objective with reproducible, durable and clinically m...
Antonio Citro, Lorenzo Piemonti· Frontiers in Bioengineering...· 0 citations
Pharmaceutical discovery and development continue to be some of the most intricate, financially demanding, and protracted pursuits in the biomedical field, with typical development periods surpassing ten years and failure rates resulting in just a minor percentage of candidates attaining approval. In the last twenty ye...
Sanmay Yadav*, Abhishek Doshi, Sarthak Kole, Mayuri Kore, Sneha Dhekane· International Journal of Med...· 0 citations
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This article examines early drug development through the lens of regulatory affairs and project management, with emphasis on readiness for Pre-IND meetings and the IND application for FDA. Sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT) are inherited blood disorders that have long needed dura...
Glutamate receptors constitute one of the most structurally diverse and functionally versatile families of signaling proteins in the animal kingdom, mediating the primary excitatory neurotransmission in the vertebrate central nervous system while also fulfilling ancestral roles in metabolic coordination, osmotic regula...
Tatiana N. Olivares-Bañuelos, Natalia Morales-Ramírez, Bolaji O. Oyetayo et al.· Receptors· 0 citations
R analysis code, preregistered decision rules, result files, run logs and figures for a study of what omitting tumor proliferation does to prognostic gene expression estimates. For every expressed gene in a cohort, two Cox models are fitted for overall survival, one adjusted for age, sex and anatomic extent and one tha...
Soon Woo Nam· Zenodo (CERN European Organi...· 0 citations
Spatial transcriptomics links gene expression to tissue structure, yet current models learn embeddings whose meaning is assigned afterwards or read histology without measured expression. Tissue decisions are therefore rarely made from morphology, genes and neighbourhood together, or examined through them. Here we intro...
Wu JinYu, Wanzhe Xu, Yizhou Zhuang et al.· bioRxiv (Cold Spring Harbor...· 0 citations
Abstract Tumor organoids are three-dimensional (3D), self-organizing cultures that have become a central experimental platform in cancer research and translational medicine. Their value lies in preserving genetic heterogeneity, reproducing patient-specific phenotypes, and supporting functional drug sensitivity testing....
Wenwen Zhao, Ling Huang, Yilun Cheng et al.· Journal of Translational Med...· 0 citations
Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a promising therapy option for a variety of malignant and nonmalignant diseases. Given their increased risk to develop certain cancer types, namely lymphoma, and the current progress with HIVenv-directed...
Lea Isabell Schwarze, Niklas Nuppenau, Jan Hendrik Müller et al.· Human Gene Therapy· 0 citations
Cereal grain is a global food staple. Filial tissues in grain, such as the embryo and endosperm, grow embedded in the maternal ovule and surrounding ovary wall. Maternal tissues provide nutrition and protection but are progressively reduced and degraded as filial tissues expand, driving grain expansion between floret h...
Jian Luo, Linsan Liu, Xiu-Juan Yang et al.· New Phytologist· 0 citations
The accumulation of mutations is the primary generator of hereditary diseases as well as ostensibly much of the symptomatology of aging. Various methods for the therapeutic repair of mutations have been devised, but most have focused on the repair of known hereditary diseases of fixed location, with none having demonst...
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.