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1,393 papers
Wheat (Triticum aestivum L.) remains one of the most important staple crops worldwide and serves as a primary source of calories and protein for billions of people. Global wheat production, however, continues to be threatened by rust diseases caused by Puccinia triticina, Puccinia striiformis f. sp. tritici and Puccini...
Clinical applications of gene editors including CRISPR-Cas9 are limited by the cell-type specificity and tissue penetrance of current in vivo delivery options. Cell-mediated gene editor delivery could overcome these obstacles. To date, systems utilizing immortalized cell lines have demonstrated gene editor delivery in...
Background: Epithelial-derived carcinomas exhibit genomic instability due to genetic mutation and epigenetic dysregulation. Mechanisms such as DNA methylation, histone modifications, and noncoding RNA regulation may lead to tumor progression, immune evasion, and treatment resistance. Presently, gene-based and epigeneti...
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Cutting-edge preclinical and translational developments with potential to redefine AATD management and move toward curative approaches are highlighted, highlighting cutting-edge preclinical and translational developments with potential to redefine AATD management.
A synthesis of male reproductive genes and regulatory pathways in Diptera according to the reproductive processes they control and the failure modes caused by their disruption can inform target prioritization, strain maintenance, and quality control of irradiated males, thereby enhancing the refinement of SIT and relat...
CRISPR-Cas systems have revolutionized microbial genome engineering, yet counter-selection strategies typically rely on targeted DNA cleavage, where the severe cytotoxicity of double-strand breaks restricts transformation efficiency and clonal recovery. Here, we present an innovative strategy, SuCas12a2-Universal Recom...
The Microprocessor complex, minimally composed of DROSHA and DGCR8, is ubiquitously required for microRNA biogenesis. It also regulates the balance between pluripotency and differentiation through mRNA alternative splicing and mRNA cleavage. However, how these various activities are regulated remains incompletely und...
Abstract Background PTPN22, a protein tyrosine phosphatase (PTP) family member, has recently emerged as an intracellular regulator in adaptive immune cells. However, its function in natural killer (NK) cells remains unclear despite its high expression in innate immune cells. Methods We analyzed single-cell RNA-sequenci...
Telomere length (TL) is highly heritable and associated with a plethora of health conditions, including cancer, Alzheimer's and coronary artery disease (CAD). A number of studies have linked TL to CAD, with short TL preceding disease onset. Genetic studies support a causal link between the two, though the mechanism rem...
The fate of cellular mRNAs is governed by intricate and dynamic post-transcriptional regulatory mechanisms that fine-tune cellular gene expression. Processes such as stabilisation, degradation, splicing, nuclear export and RNA editing, are essential for mRNA processing and are known to be hijacked by RNA viruses to enh...
GPT-Lab
· gpt-lab.eu
Oct 8, 2026
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
A Blog post by Ai2 on Hugging Face
A Blog post by ServiceNow-AI on Hugging Face
“InstructMesh” can generate designs for everyday objects that are easy to edit and fabricate for both experts and newcomers to 3D modeling.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
Algorithms & Theory
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