This review summarizes recent progress in elucidating plant virus-vector molecular interactions and their potential use in innovative strategies for virus and vector control.
B. Bonning· Current Opinion in Virology· 0 citations
An RNA-guided bridge recombinase system is engineered through rational mutagenesis and AI-assisted directed evolution, enabling programmable chromosomal rearrangements in both plant and mammalian cells and achieving up to a 29.8-fold increase in activity.
Rui Gao, Jingjing Wei, Chao Sun et al.· Trends in Biotechnology· 0 citations
Compared with conventional homologous recombination, the CRISPR-Cas9 system substantially improved gene disruption efficiency, thereby overcoming a major limitation in the genetic manipulation of lichen-forming fungi.
Ze-Yi Wang, Niu-Niu Wang, Hai-Yu Zhang et al.· Journal of Fungi· 0 citations
This first-in-human study demonstrated the feasibility of an "off-the-shelf" base-edited CAR T cell approach and informs future multiantigen strategies against AML.
C. Georgiadis, Robert Chiesa, Hebatalla Rashed et al.· Science Translational Medici...· 0 citations
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Cell-specific epigenetic editing holds very high therapeutic value for atherosclerosis, cardiomyopathy, and fibrosis, provided that delivery, specificity, and safety challenges are also addressed.
Majed Alsulami, M. Rasool, Ahmed Masoud et al.· The Cardiology· 0 citations
This synthesis provides a framework for translating mechanistic hormonal insights into field-applicable cultivars to ensure global food security and proposes a systems-level roadmap for developing climate-resilient rice cultivars capable of maintaining yield stability across a volatile combinatorial stress landscape.
Shui-Xing Zhu, Jing Zhu, Dikhnah Alshehri et al.· Frontiers in Plant Science· 0 citations
Results indicate that targeted reactivation of BFL-1 and SQOR increases cell-death susceptibility in liver cancer cells, providing proof-of-concept for locus-specific epigenetic therapy in liver cancer.
Wonjin Woo, Seol-Hwa Jeong, Ayoung Hwang et al.· Molecules and Cells· 0 citations
This targeted modification markedly improved rice eating and cooking quality while maintaining the levels of total starch, total protein, and key agronomic traits.
Zhihui Chen, Yu Chen, Gexing Wan et al.· Journal of Integrative Plant...· 0 citations
Post-training alignment is often shallow, eroding under fine-tuning. It remains untested as to whether constitutional midtraining interventions can produce durable alignment when cleanly isolated from post-training. We build a 394M-token constitutional corpus from Anthropic's Constitution and apply constitutional midtr...
D. Cho, Cameron Tice, Bernie Hogan et al.· arXiv.org· 1 citation
It is demonstrated that local nucleosome sequence and structure profoundly influence Cas nuclease accessibility and specificity, with HIFIv1 emerging as the top-performing nuclease for nucleosomal targets, while evoSpCas9 excelled in exposed contexts.
Christopher Handelmann, Erin Skeens, George P. Lisi et al.· Frontiers in Genome Editing· 0 citations
Exposure to airborne nickel in the average daily dose, combined with the minor C-allele and CC-genotype of the VEGFA induces changes in indices of cell death and the immune profile in adults in the Far North (declining AnnexinV-FITC+7AAD– levels, growing levels of VEGF and IgE to nickel).
N. Zaitseva, N. Nikonoshina, O. V. Dolgikh et al.· Hygiene and Sanitation· 0 citations
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