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gene editing

1,461 papers

#gene editing Aug 2026

Engineering RNA-guided bridge recombinases for precise large-scale genome editing.

An RNA-guided bridge recombinase system is engineered through rational mutagenesis and AI-assisted directed evolution, enabling programmable chromosomal rearrangements in both plant and mammalian cells and achieving up to a 29.8-fold increase in activity.

Rui Gao, Jingjing Wei, Chao Sun et al. · 0 citations
#gene editing Open access Aug 2026

Establishment of an Efficient CRISPR-Cas9-Mediated Gene Disruption System in the Lichen-Forming Fungus Umbilicaria muhlenbergii

Compared with conventional homologous recombination, the CRISPR-Cas9 system substantially improved gene disruption efficiency, thereby overcoming a major limitation in the genetic manipulation of lichen-forming fungi.

Ze-Yi Wang, Niu-Niu Wang, Hai-Yu Zhang et al. · 0 citations
#gene editing Review Aug 2026

Cell-specific epigenetic editing in cardiovascular disease: Mechanisms, therapeutic potential, and translational challenges.

Cell-specific epigenetic editing holds very high therapeutic value for atherosclerosis, cardiomyopathy, and fibrosis, provided that delivery, specificity, and safety challenges are also addressed.

Majed Alsulami, M. Rasool, Ahmed Masoud et al. · 0 citations
#gene editing Review Open access Aug 2026

Hormone priming and metabolic engineering of phytohormone crosstalk in rice under combined biotic and abiotic stresses: a multi-omics perspective for climate-resilient crop development

This synthesis provides a framework for translating mechanistic hormonal insights into field-applicable cultivars to ensure global food security and proposes a systems-level roadmap for developing climate-resilient rice cultivars capable of maintaining yield stability across a volatile combinatorial stress landscape.

Shui-Xing Zhu, Jing Zhu, Dikhnah Alshehri et al. · 0 citations

Constitutional Midtraining: Content Presence Drives Alignment Gains

Post-training alignment is often shallow, eroding under fine-tuning. It remains untested as to whether constitutional midtraining interventions can produce durable alignment when cleanly isolated from post-training. We build a 394M-token constitutional corpus from Anthropic's Constitution and apply constitutional midtr...

D. Cho, Cameron Tice, Bernie Hogan et al. · 1 citation
#gene editing Open access Aug 2026

Evaluating high-fidelity CRISPR-Cas nucleases in nucleosomal contexts using a quantitative framework

It is demonstrated that local nucleosome sequence and structure profoundly influence Cas nuclease accessibility and specificity, with HIFIv1 emerging as the top-performing nuclease for nucleosomal targets, while evoSpCas9 excelled in exposed contexts.

Christopher Handelmann, Erin Skeens, George P. Lisi et al. · 0 citations
#gene editing Open access Aug 2026

Polymorphism of the <i>VEGFA</i> (rs2010963) gene and low-dose exposure to airborne nickel as modification factors of programmed cell death in the Far North residents

Exposure to airborne nickel in the average daily dose, combined with the minor C-allele and CC-genotype of the VEGFA induces changes in indices of cell death and the immune profile in adults in the Far North (declining AnnexinV-FITC+7AAD– levels, growing levels of VEGF and IgE to nickel).

N. Zaitseva, N. Nikonoshina, O. V. Dolgikh et al. · 0 citations

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