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gene editing

1,360 papers

#gene editing Open access Oct 2026

Advancing cardiac xenotransplantation: overcoming challenges and ethical considerations for clinical integration

Advanced heart failure affects over 6 million adults in the United States alone. Orthotopic heart transplantation remains the definitive treatment, with over 90% one-year survival and meaningful gains in functional status and quality of life. The therapy is, however, constrained by an intractable supply problem. For de...

A. Abdelrehim, D. Hurst, W. H. Gray et al. · 0 citations
#protein folding Open access Oct 2026

Mutation-induced penicillin binding protein 2A inactivation through CRISPR-dCas9 gene editing in methicillin-resistant S. aureus

Background and Objectives: The global rise of antimicrobial resistance threatens effective treatment of bacterial infec- tions. Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen whose resistance to β-lactam antibiotics is primarily mediated by the  mecA gene, encoding the low-affinity penicillin-bi...

Arooj Khan, Adnan Iqbal, Husnain Athar et al. · 0 citations
#gene editing Review Open access Oct 2026

From Genomics to Precision Cardiology: A Comprehensive Review of Clinical Applications and Challenges in Cardiovascular Diseases

Genomic cardiology has substantial potential to advance precision cardiovascular medicine and continued development of diverse genomic databases, standardized clinical implementation frameworks, and emerging genomic therapies will be important for translating genomic advances into equitable and clinically meaningful ca...

N. Mohsen-Pour, Shiva Esmaeili, Aydin Feyzi et al. · 0 citations
#gene editing Review Open access Oct 2026

Combining Antiviral Therapy with Cancer Treatment in HBV-associated HCC: A Translational Approach.

This review examines the emerging concept of combining antiviral and anticancer strategies to improve clinical outcomes in HBV-HCC and highlights recent translational studies, clinical trials, and future directions that support a dual-modality approach.

M. Hashem, M. E. H. Kayesh, M. Kohara et al. · 0 citations
#gene editing Open access Oct 2026

Establishing a Transgenic Chicken Line Expressing Human Teriparatide Therapeutic Protein for Treating Osteoporosis

Osteoporosis is an emerging public health burden in India, affecting around 61 million people, while post-menopausal women accounting for 80% of the affected population. Teriparatide, a recombinant human parathyroid hormone (PTH 1–34), is commonly used for the treatment of severe osteoporosis. It has an anabolic effect...

Devender Singh, Sayan Kundu, Arpita Sahoo et al. · 0 citations
#gene editing Open access Oct 2026

Establishing a Transgenic Chicken Line Expressing Human Teriparatide Therapeutic Protein for Treating Osteoporosis

Osteoporosis is an emerging public health burden in India, affecting around 61 million people, while post-menopausal women accounting for 80% of the affected population. Teriparatide, a recombinant human parathyroid hormone (PTH 1–34), is commonly used for the treatment of severe osteoporosis. It has an anabolic effect...

Devender Singh, Sayan Kundu, Arpita Sahoo et al. · 0 citations
#gene editing Open access Oct 2026

Advances in Genome Editing and Genome Engineering Toolbox for Improving Livestock Health and Productivity

Introduction An ever-growing world population with increased income causes significant rises in the demand for livestock products such as dairy and meat. From 2020 to 2050, global demand for livestock products is projected to increase by 8%, and per capita protein requirements will rise by 38% (Komarek et al., 2021). I...

Sudeepta Kumar Panda, Gyanendra Singh · 0 citations
#gene editing Open access Oct 2026

Advances in Genome Editing and Genome Engineering Toolbox for Improving Livestock Health and Productivity

Introduction An ever-growing world population with increased income causes significant rises in the demand for livestock products such as dairy and meat. From 2020 to 2050, global demand for livestock products is projected to increase by 8%, and per capita protein requirements will rise by 38% (Komarek et al., 2021). I...

Sudeepta Kumar Panda, Gyanendra Singh · 0 citations
#gene editing Open access Oct 2026

CRISPR/Cas9-Mediated MSTN Knockout Alters Muscle Proteome and MSTN–ACVR2B Interaction in Buffalo Myoblasts

Myostatin (MSTN) is a potent negative regulator of skeletal muscle growth and differentiation. Buffalo myoblasts were isolated from the longissimus dorsi muscle and characterized by binucleate morphology and Pax7/myosin immunostaining. Myoblasts were nucleofected with MSTN guide RNA and Cas9, and three independently de...

Meeti Punetha, Sristi Bhatia, Bhavya Magoo et al. · 0 citations
#gene editing Open access Oct 2026

Integration of MOET and CRISPR/Cas9 RNP electroporation for MSTN genome editing in caprine zygotes

Myostatin (MSTN) is a key negative regulator of skeletal muscle growth and an important candidate gene for genetic improvement of economically relevant livestock traits. CRISPR/Cas9-mediated genome editing using ribonucleoprotein (RNP) delivery offers a precise approach for targeted MSTN modification in caprine embryos...

SHIVA PRATAP SINGH, Juhi Pathak, Manisha Pathak et al. · 0 citations
#gene editing Open access Oct 2026

Integration of MOET and CRISPR/Cas9 RNP electroporation for MSTN genome editing in caprine zygotes

Myostatin (MSTN) is a key negative regulator of skeletal muscle growth and an important candidate gene for genetic improvement of economically relevant livestock traits. CRISPR/Cas9-mediated genome editing using ribonucleoprotein (RNP) delivery offers a precise approach for targeted MSTN modification in caprine embryos...

SHIVA PRATAP SINGH, Juhi Pathak, Manisha Pathak et al. · 0 citations
#gene editing Open access Oct 2026

CRISPR/Cas9-Mediated MSTN Knockout Alters Muscle Proteome and MSTN–ACVR2B Interaction in Buffalo Myoblasts

Myostatin (MSTN) is a potent negative regulator of skeletal muscle growth and differentiation. Buffalo myoblasts were isolated from the longissimus dorsi muscle and characterized by binucleate morphology and Pax7/myosin immunostaining. Myoblasts were nucleofected with MSTN guide RNA and Cas9, and three independently de...

Meeti Punetha, Sristi Bhatia, Bhavya Magoo et al. · 0 citations

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Google DeepMind Blog Sep 30, 2026

Introducing SynthID Bio

Proof of concept for watermarking AI-generated proteins while preserving biological function.

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