This review summarizes recent advances in non-viral gene-delivery platforms, compares their strengths and limitations, and discusses future directions in cell-selective delivery, endosomal escape, transient delivery of genome-editing machinery, engineered EVs, hybrid vectors, and manufacturing-oriented development.
वैज्ञानिक अनुसंधान प्रस्ताव (Research Article Proposal)शीर्षक (Title): हंटिंगटन रोग के न्यूरो-रीजनरेशन के लिए मल्टी-टार्गेटेड जीन-एंटीबॉडी नैनोथेराप्यूटिक कास्केड का कार्यान्वयनआविष्कारक का नाम (Inventor Name): बंटी कुमावत (Banti Kumawat)वर्ष (Year): 2026🔬 1. प्रस्तावना (Introduction)हंटिंगटन रोग (Huntington's Disease...
Banti kumawat Kumawat· Zenodo (CERN European Organi...· 0 citations
Joubert syndrome (JS) is a rare, genetically heterogeneous autosomal recessive ciliopathy characterized by the pathognomonic molar tooth sign (MTS) on brain magnetic resonance imaging, resulting from cerebellar vermis hypoplasia or aplasia and abnormal superior cerebellar peduncles. Since its first description by Marie...
In the field of regenerative medicine, developing stem cell therapy and tissue engineering has become a game-changing strategy that holds promise for replacing and repairing damaged organs and tissues. Innovative biological interventions are required since traditional therapy approaches frequently fail to restore total...
Pravin Patil, Vivek Kale, Tanaya Ware et al.· Zenodo (CERN European Organi...· 0 citations
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वैज्ञानिक अनुसंधान प्रस्ताव (Research Article Proposal)शीर्षक (Title): हंटिंगटन रोग के न्यूरो-रीजनरेशन के लिए मल्टी-टार्गेटेड जीन-एंटीबॉडी नैनोथेराप्यूटिक कास्केड का कार्यान्वयनआविष्कारक का नाम (Inventor Name): बंटी कुमावत (Banti Kumawat)वर्ष (Year): 2026🔬 1. प्रस्तावना (Introduction)हंटिंगटन रोग (Huntington's Disease...
Banti kumawat Kumawat· Zenodo (CERN European Organi...· 0 citations
The use of an adenine base editor (ABE) to directly correct SCN1AR613X, a recurrent variant found in patients with DS, suggests the therapeutic potential of prime editing for the treatment of patients with SCN1A-associated GEFS+.
Samantha A Dow, Tracy A. Bedrosian· Epilepsy Currents· 0 citations
Nonviral NPs are poised to redefine CAR therapy by enabling scalable, off-the-shelf immune interventions for cancer, autoimmune, and fibrotic diseases.
Ke Huang, Hao Wang, Tao Zhu et al.· Biomaterials· 1 citation
Step-by-step methods for deploying CRISPR/Cas9 to engineer a TERT-immortalized human epidermal keratinocyte line (N/TERT-2G) to generate monoclonal heterozygous and homozygous knockout cell lines are described.
Anthony Coon, Jessica L. Ayers, Christopher Cole et al.· Methods in molecular biology· 0 citations
Adipose‐derived stromal vascular fraction (SVF)‐gel has an autologous origin and favorable immunocompatibility and exhibits favorable safety and efficacy in facilitating cartilage regeneration and repair.
This review dissects the differential regulatory mechanisms of ICD-mediated immune memory in CNS tumors versus non-tumor diseases and aims to elucidate the molecular switches that govern the transition of this immune program from a beneficial, compensatory state to a pathological, detrimental phenotype.
Peng-Fei Li, Zi-Lin Zhou, Yong-Zhi Qing et al.· Ageing Research Reviews· 0 citations
The convergence of fungal systems biology with the principles of circular bioeconomy is illustrated and the technological, economic, and regulatory bottlenecks which need to be overcome are pointed out to fully realise the potential of fungi as the biofactories of the future for the sustainable production of energy and...
B. Thakur, Sukhminderjit Kaur, Ranjan Singh et al.· Journal of Pure and Applied...· 0 citations
An Evaluation Agent, middleware that combines Natural Language Inference factual verification, a five-signal poison detector with relevance-weighted aggregation, and a Trust Index is proposed, which reliably blocks instruction injection of unsafe advice while contradiction and subtle semantic weakening remain hard.
Balkrishna Giri, M. Hasan, Jussi Rasku et al.· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
