DiffusionGemma: 4x faster text generation
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Unlocking non-model organisms with CRISPR-Cas: A roadmap for sustainable biotechnology.
It is concluded that bridging the gap between foundational CRISPR research and its real-world applications is imperative and future efforts should focus on democratizing tools via open-source platforms, advancing delivery systems, and fostering sustainable innovation through synthetic biology integration to fully realize the transformative potential of genome editing in organisms beyond model organisms.
Mutation-induced phenotypic plasticity drives formation of a pro-metastatic tumour-intrinsic niche
It is argued that formation of a tumour-intrinsic niche is a prerequisite for BRAF-mutant CRC seeding to distant organs and that interference with niche formation may help avoid metastatic relapse.
Modelling the impact of temperature on nanocarrier behavior: Thermodynamics, structural transitions, and drug release.
A rational design for next-generation thermo-responsive nanocarriers is proposed, in which polymer chemistry, nanoparticle structure, experimental characterization, and mechanistic modelling are integrated from the earliest stages of material development.
Modeling Environmentally Driven Seasonal Moisture Migration and Ground Movements in Expansive Clays
This paper describes the formulation of a numerical model for simulating environmentally driven one-dimensional (1D) ground movements of expansive clay. The formulation is based on a finite-element model that simulates the redistribution of matric suction through a diffusion-type equation, explicitly accounting for volume changes due to wetting and drying of the clay. We synthesize and modify highly nonlinear constitutive relationships for (1) hysteretic soil water retention; (2) reversible soil shrinkage and expansion of clay; and (3) hydraulic conductivity, explicitly incorporating desiccation cracks through a multidomain framework and assuming a critical surface crack depth. These models are well-calibrated to published laboratory tests on a reference expansive clay, Denver bentonite. We demonstrate capabilities of the proposed formulation to simulate the response of a homogeneous expansive clay to periods of drying and wetting, considering the initial matric suction, saturated hydraulic conductivity of the intact clay, and critical crack depth as three primary sources of uncertainty. We compare ensemble model simulations with measured ground movements from an instrumented expansive clay test site in Texas over a 3-year period using detailed records of potential evapotranspiration and precipitation. By assigning weights to the ensemble simulations based on their performance, we constrain the ranges of the three key uncertain parameters. The results showed very reasonable first-order agreement with the measured data and highlight the potential of the proposed formulation. We anticipate that more reliable predictions can be achieved through direct measurements of actual in situ evaporation rates and local soil properties.