#gene editing
Oct 2026
Generation of DFNA5-deficient chickens reveals a species-specific role of pyroptosis in avian antiviral immunity
This work establishes the first germline-edited heterozygous DFNA5-mutant chicken model using primordial germ cell mediated genome editing and demonstrates that genetic disruption of DFNA5 markedly attenuates Raptinal-induced pyroptosis and reduces IL-1β and IL-18 secretion.
Jin-Gui Hao, Fei-Yi Wang, Man Xue et al.
· Transgenic research · 0 citations