Gene dosage effect and reduced core fucosylation in B lymphocytes of FUT8 heterozygous mice
Core fucosylation (alpha1,6-fucosylation) of N-glycans, catalyzed solely by fucosyltransferase 8 (FUT8), plays important roles in development, immunity, and antibody effector functions. Here we report the generation of Fut8 floxed mice using a CRISPR/Cas9-based Extreme Genome Editing (EGE) system, in which loxP sites f...
Yue Ma, Jing-Xia Wang, Jing-Qing Liu et al.
· bioRxiv · 0 citations