Pre-specification analysis plan: two-sample Mendelian randomization of whole-blood cis-eQTLs for ESR1 and three neighbouring skeletal genes against fracture risk
This record is the pre-specification analysis plan for a two-sample Mendelian randomization (MR) study of fracture risk, submitted to the Journal of Bone and Mineral Research (JBMR). Scope. Two-sample MR of four pre-specified cis-eQTL instruments from whole blood (eQTLGen Phase-I, N = 31,684) -- ESR1 and its neighbours...