Zheng-Guang Zhang

Targeting a cryptic Magnaporthe oryzae-specific pocket in succinate dehydrogenase to combat rice blast.

The global efficacy of succinate dehydrogenase inhibitors (SDHIs), a leading class of fungicides, is increasingly threatened by resistance, driven largely by their shared binding mode at the conserved ubiquinone-binding (Q) site. This challenge is particularly acute for rice blast, as no SDHI is registered for this dis...