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Author

Zhe Ji

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Open access Sep 2026

Cotranslational membrane protein biogenesis by an EMC-bound translocon.

Secretory and membrane protein biogenesis occurs at ribosome-bound translocons in the endoplasmic reticulum (ER) membrane. Translocons consist of the Sec61 protein-conducting channel and various maturation factors including chaperones, modification enzymes and membrane insertases, which assemble dynamically in response...

Madeline G. Rollins, Josephine Tang, Yu Wan et al. · 0 citations
#gene editing Open access Aug 2026

An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2.

A single uORF in KCNQ2 is identified that is highly repressive of protein translation and it is demonstrated that mutations disabling the uORF start codon enhance synthesis of encoded potassium channels and weaken ribosome engagement at the uORF.

D. Huey, Eduardo Guadarrama, J. DeKeyser et al. · 0 citations

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