Zephyr Lenninger

Overexpressing FLP Recombinase Can Cause Synaptic Trafficking Defects in C. elegans

Site-specific recombinases, such as Cre recombinase (Cre) and FLP recombinase (FLPase), are popular tools that enable precise spatiotemporal control over fluorescent reporter genes. However, studies show that increased Cre expression can lead to cytotoxic phenotypes including DNA damage, cell cycle arrest, cell death,...