Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.
A virus-like particle (VLP)-based toolkit that delivers diverse CRISPR editing modalities to human monocytes, macrophages and dendritic cells with high efficiency while preserving viability and innate immune responsiveness is presented.
Hyuncheol Jung, Pascal Devant, Carter Ching et al.
· Nature Biotechnology · 0 citations