Author

Zachary Steinhart

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Open access Aug 2026

A genome-wide CRISPR activation map of surface protein expression in human CD4 T cells

SCITO-Perturb-seq represents the first genome-wide CRISPRa screen paired with direct, high-dimensional surface protein profiling, providing a comprehensive regulatory map of the CD4 T cell surface proteome.

Yutong V. Wang, Junha Park, Min Cheol Kim et al. · bioRxiv · 0 citations

#gene editing Open access Aug 2026

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.

A virus-like particle (VLP)-based toolkit that delivers diverse CRISPR editing modalities to human monocytes, macrophages and dendritic cells with high efficiency while preserving viability and innate immune responsiveness is presented.

Hyuncheol Jung, Pascal Devant, Carter Ching et al. · Nature Biotechnology · 0 citations