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Z. Safaei

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Review Open access Sep 2026

HIV cure: from early therapies to cutting-edge strategies

This review highlights CRISPR’s potential to provide durable, scalable, and cost-effective HIV control, particularly in low-resource settings and underscores a hopeful vision that precise gene editing may transform HIV therapy from lifelong suppression into a pathway toward functional cure.

Z. Safaei, K. Khalili · 0 citations
#gene editing Review Open access Sep 2026

HIV cure: from early therapies to cutting-edge strategies

HIV has challenged humanity for decades, quietly establishing latent reservoirs that evade even the most potent antiretroviral therapies (ART). While ART transformed HIV from a fatal disease into a manageable condition, the virus’s hidden persistence continues to fuel the global epidemic. This review narrates the story...

Z. Safaei, K. Khalili · 0 citations
#gene editing Open access Aug 2026

Triple-Target CRISPR Strategy to Block HIV Entry and Replication in Permissive Cells

The combination knockout of CCR5, MOGS, and viral sequences profoundly reduces HIV-1 replication in an ex vivo cellular model, that is, HIV-1-infected peripheral blood mononuclear human cells, thus offering a pathway to launch further preclinical studies.

Z. Safaei, Anna Bellizzi, Hong Liu et al. · 0 citations

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